中国科学技术大学高大兴--中文主页--首页

基本信息
科学研究

个人简介

博士生导师，中国科学技术大学教授，国家创新人才项目入选者。本科毕业于中国科学技术大学，博士毕业于美国西南医学中心。 2016-2019年在美国洛克菲勒大学任博士后。主要从事核酸天然免疫调控与识别，及其与抗病毒免疫以及自身免疫病关系的研究，研究成果发表于Science, Science Immunology, Nature Medicine，JCI，PNAS等期刊上，论文被引用2500余次。承担国家自然科学基金委课题，中科院先导项目和科技部重点研发计划。

教育经历

[1] 2021年9月~2021年9月， 2006-2010年，中国科学技术大学生命科学学院，获学士学位

[2] 2021年9月~2021年9月， 2010-2015年，美国得克萨斯大学西南医学中心，获免疫学博士学位

工作经历

[1] 2016年2月~2019年10月，美国洛克菲勒大学，博士后

[2] 2019年10月~至今，中国科学技术大学，生医部，教授

团队成员更多

研究方向

[1] 核酸天然免疫识别

[2] S. Ru, S. Tang, H. Xu, J. Yin, Y. Guo, L. Song, Z. Jin, D. Lee, Y.-H. Chan, X. Chen, L. Buerer, W. Fairbrother, W. Jia, J.-L. Casanova, S.-Y. Zhang, D. Gao, Human DBR1 deficiency impairs stress granule-dependent PKR antiviral immunity. J Exp Med 222, e20240010 (2025)..2025,

[3] Z. Jiang, F. Shi, J. Li, R. Liu, J. Zhou, Z. Zhong, C. Shi, M. Ma, S. Xiang, D. Gao, Crucial role of the cGAS N terminus in mediating flowable and functional cGAS-DNA condensate formation via DNA interactions. Proc Natl Acad Sci U S A 122, e2411659122 (2025)..2025,

[4] Y. Qu, Z. Li, J. Yin, H. Huang, J. Ma, Z. Jiang, Q. Zhou, Y. Tang, Y. Li, M. Huang, Z. Zeng, A. Guo, F. Fang, Y. Shen, R. Zhao, Y. Wang, D. Gao, cGAS mRNA-based Immune Agonist Promotes Vaccine Responses and Antitumor Immunity. Cancer Immunol Res, doi: 10.1158/2326-6066.CIR-24-0804 (2025)..2025,

[5] Y.-H. Chan, V. Lundberg, J. Le Pen, J. Yuan, D. Lee, F. Pinci, S. Volpi, K. Nakajima, V. Bondet, S. Åkesson, N. V. Khobrekar, A. Bodansky, L. Du, T. Melander, A.-A. Mariaggi, Y. Seeleuthner, T. S. Saleh, D. Chakravarty, P. Marits, K. Dobbs, S. Vonlanthen, V. Hennings, K. Thörn, D. Rinchai, L. Bizien, M. Chaldebas, A. Sobh, T. Özçelik, S. Keles, S. A. AlKhater, C. Prando, I. Meyts, COVID Human Genetic Effort, M. R. Wilson, J. Rosain, E. Jouanguy, M. Aubart, L. Abel, T. H. Mogensen, Q. Pan-Hammarström, D. Gao, D. Duffy, A. Cobat, S. Berg, L. D. Notarangelo, O. Harschnitz, C. M. Rice, L. Studer, J.-L. Casanova, O. Ekwall, S.-Y. Zhang, SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency. J Exp Med 221, e20231725 (2024)..2024,

[6] D. Ma, A. Xie, J. Lv, X. Min, X. Zhang, Q. Zhou, D. Gao, E. Wang, L. Gao, L. Cheng, S. Liu, Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins. Protein Cell, pwae015 (2024)..2024,

[7] D. Gao, M. J. Ciancanelli, P. Zhang, O. Harschnitz, V. Bondet, M. Hasek, J. Chen, X. Mu, Y. Itan, A. Cobat, V. Sancho-Shimizu, B. Bigio, L. Lorenzo, G. Ciceri, J. McAlpine, E. Anguiano, E. Jouanguy, D. Chaussabel, I. Meyts, M. S. Diamond, L. Abel, S. Hur, G. A. Smith, L. Notarangelo, D. Duffy, L. Studer, J.-L. Casanova, S.-Y. Zhang, TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons. Journal of Clinical Investigation 131 (2021)..2021,

[8] D. Gao, J. Wu, Y. T. Wu, F. Du, C. Aroh, N. Yan, L. Sun, Z. J. Chen, Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science (New York, N.Y.) 341, 903–906 (2013).2013,

[9] F. G. Lafaille, O. Harschnitz, Y. S. Lee, P. Zhang, M. L. Hasek, G. Kerner, Y. Itan, O. Ewaleifoh, F. Rapaport, T. M. Carlile, M. E. Carter-Timofte, D. Paquet, K. Dobbs, B. Zimmer, D. Gao, M. F. Rojas-Duran, D. Kwart, V. Rattina, M. J. Ciancanelli, J. L. McAlpine, L. Lorenzo, S. Boucherit, F. Rozenberg, R. Halwani, B. Henry, N. Amenzoui, Z. Alsum, L. Marques, J. A. Church, S. Al-Muhsen, M. Tardieu, A. A. Bousfiha, S. R. Paludan, T. H. Mogensen, L. Quintana-Murci, M. Tessier-Lavigne,G. A. Smith, L. D. Notarangelo, L. Studer, W. Gilbert, L. Abel, J. L. Casanova, S. Y. Zhang, Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis. Nature Medicine 25, 1873–1884 (2019)..2019,

[10] D. Gao, T. Li, X.-D. Li, X. Chen, Q.-Z. Li, M. Wight-Carter, Z. J. Chen, Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases. Proceedings of the National Academy of Sciences 112, E5699–E5705 (2015)..2015,