Impact Factor: 7.9

DOI number: 10.1038/s41378-023-00603-2

Journal: Microsystems & Nanoengineering

Abstract: Osmotic pressure is vital to many physiological activities, such as cell proliferation, wound healing and disease treatment. However, how cells interact with the extracellular matrix (ECM) when subjected to osmotic shock remains unclear. Here, we visualize the mechanical interactions between cells and the ECM during osmotic shock by quantifying the dynamic evolution of the cell traction force. We show that both hypertonic and hypotonic shocks induce continuous and large changes in cell traction force. Moreover, the traction force varies with cell volume: the traction force increases as cells shrink and decreases as cells swell. However, the direction of the traction force is independent of cell volume changes and is always toward the center of the cell-substrate interface. Furthermore, we reveal a mechanical mechanism in which the change in cortical tension caused by osmotic shock leads to the variation in traction …

First Author: Yongman Liu

Indexed by: Journal paper

Correspondence Author: Shangquan Wu,Qingchuan Zhang

Volume: 9

Issue: 1

Page Number: 131

Translation or Not: no

Date of Publication: 2023-10-16

Included Journals: SCI

Links to published journals: https://www.nature.com/articles/s41378-023-00603-2