中国科学技术大学教授，附属第一医院特聘教授，博士生导师，入选国家海外高层次人才计划和中科院青年人才计划。2015年博士毕业于中国科学技术大学,之后先后在美国华盛顿大学、耶鲁大学和加州大学洛杉矶分校任博士后和助理研究员。2023年4月加入中国科学技术大学生命科学与医学部，组建心血管代谢实验室。研究采用系统遗传学和多组学方法探究心衰的病理生理机制，主要工作以第一或通讯作者（含共同）发表于Science，Circulation，Nature Aging (2025), Cell Metabolism（2024a, 2024b），Circulation Research (2017, 2024), Nature Communications, EMBO Journal等期刊上。

研究方向：

1）器官间相互作用对心力衰竭发生发展的影响；

2）系统遗传学方法解析心力衰竭的遗传机制；

3）线粒体和代谢在心衰中的作用；

招生方向：细胞生物学，分子生物学，生物信息学，基础医学等相关方向

发表文章：

1. Cao Y, Wang Y-C, Zhou Z, Pan C, Jiang L, Zhou Z, Meng Y, Charugundla S, Li T, Allayee H, Seldin MM, and Lusis AJ. Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure. Science. 2022;377(6613):1399-1406. PubMed PMID: 36137043.

2. Wang YC, Koay YC, Pan C, Zhou Z, Wilson Tang WH, Wilcox J, Li XS, Zagouras A, Marques F, Allayee H, Rey FE, Kaye DM, O'Sullivan JF, Hazen SL, Cao Y*, and Lusis AJ*. Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction. Circulation Research. 2024 Feb 16;134(4):371-389. PubMed PMID: 38264909. (Featured article, Best Manuscript Award)

3. Zhou J^#, Zhang L^#, Peng J^#, Zhang X^#, Zhang F^#, Wu Y, Huang A, Du F, Liao Y, He Y, Xie Y, Gu L, Kuang C, Ou W, Xie M, Tu T, Pang J, Zhang D, Guo K, Feng Y, Yin S, Cao Y*,  Li T*, Jiang Y*. Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation. Cell Metab. 2024 Jun 14:S1550-4131(24)00192-X. PMID: 38906140.

4. He Q^#, Ji L^#, Wang Y^#, Zhang Y^#, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y*, Li T*. Acetate enables metabolic fitness and cognitive performance during sleep disruption. Cell Metab. 2024 Sep 3;36(9):1998-2014.e15. doi: 10.1016/j.cmet.2024.07.019. Epub 2024 Aug 19. PMID: 39163862.

5. Zuo X^#, Zhao R^#, Wu M^#, Wang Y^#, Wang S^#, Tang K, Wang Y, Chen J, Yan X*, Cao Y*, Li T*. Multi-omic profiling of sarcopenia identifies disrupted      branched-chain amino acid catabolism as a causal mechanism and therapeutic target. Nature Aging. 2025

6. Cao Y, Pan C, Wang Y-C, Zhou Z, Jedian V, Meng Y, Campbell G, Guardino K, Li C, Wang J, and Lusis AJ. Identification of DNA Damage Repair Enzyme Ascc2 as Causal for Heart Failure with Preserved Ejection Fraction (HFpEF). Circulation. 2022 Apr 5;145(14):1102-1104. PubMed PMID: 35377742.

7. Cao Y, Vergnes L, Wang Y-C, Pan C, Krishnan KC, Moore TM, Rosa-Garrido M, Kimball TH, Zhou Z, Charugundla S, Rau CD, Seldin MM, Wang J, Vondriska TM, Wang Y, Reue K, and Lusis AJ. Sex Differences in Heart Mitochondria Regulate Diastolic Dysfunction. Nature Communications. 13, 3850 (2022). PubMed  PMID: 35787630.

8. Shen S, Tian B, Zhang H, Wang YC, Li T*, Cao Y*.  Heart Failure and Gut Microbiota: What Is Cause and Effect? Research  (Wash D C). 2025 Feb 20;8:0610. doi: 10.34133/research.0610. PubMed PMID: 39981296.

9. Cao Y^#, Bojjireddy N^#, Kim M, Li T, Zhai P, Nagarajan N, Sadoshima J, Palmiter RD, Tian R. Activation of γ2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury. Circulation Research. 2017 Oct 27;121(10):1182-1191. PubMed PMID: 28835357.

10. Cao Y^#, Guo WT^#, Tian S, He X, Wang XW, Liu X, Gu KL, Ma X, Huang D, Hu L, Cai Y, Zhang H, Wang Y*, Gao P*. miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency. EMBO J. 2015 Mar 4;34(5):609-23. PubMed PMID: 25603933.

11.  Cao Y^#, Aquino-Martinez R^#, Hutchison E^#, Allayee H, Lusis AJ*, and Rey FE. Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach. Mol Metab. 2022 Jul 20:101557. PubMed PMID: 35870705.

12. Cao Y*, Lusis AJ, Coagulation factor with potential for the treatment of heart failure. Clin Transl Med. 2022; 00: e1144.

13. Wang YC, Cao Y, Pan C., Zhou Z, Lusis AJ. Heterogeneity of small intestinal immune and epithelial cells and their cellular response network to a western diet. Journal of Experimental Medicine. 2023 220 (5): e20221437.

14. Moore T, Cheng L, Wolf D, Ngo J, Segawa M, Zhu X, Strumwasser A, Cao Y, Clifford B, Ma A, Scumpia P, Shirihai O, Vallim T, Laakso M, Lusis AJ, Hevener A, Zhenqi Zhou. Parkin Regulates Adiposity by Coordinating Mitophagy with Mitochondrial Biogenesis in White Adipocytes. Nature Communications. 2022;13(1):6661. Published 2022 Nov 4. PubMed PMID: 36333379.

招生招聘：

1. 实验室常年诚挚招聘具有细胞生物学、分子生物学、生物信息学或基础医学等相关研究背景的博士后和副研究员。

2. 实验室常年热忱欢迎对本课题组研究方向感兴趣的本科生、研究生前来交流和攻读博士学位或进行本科毕业论文研究。