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陈永艳

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学位：博士

基本信息
科学研究

研究方向

[1] As a member of the lab of Tian Zhigang, I am attempting to study the innate immunity of liver

[2] The biology of the overwhelming innate immune system including NK cells and NKT cells in the liver, and their roles during HBV infection and HBV-associated liver diseases

[3] The mechanisms of HBV-induced liver immunotolerance

论文成果

[1] 3.Chen Y, Sun R, Jiang W, Wei H, Tian Z. Liver-specific HBsAg transgenic mice are over-sensitive to Poly(I:C)-induced liver injury in NK cell- and IFN-gamma-dependent manner. J Hepatol. 2007; 47(2):183-190..2021,

[2] 2.Chen Y, Wei H, Sun R, Dong Z, Zhang J, Tian Z. Increased susceptibility to liver injury in hepatitis B virus transgenic mice involves NKG2D-ligand interaction and natural killer cells. Hepatology. 2007; 46(3):706-715..2021,

[3] 1.Zhang W, Chen Y, Wei H, Zheng C, Sun R, Zhang J, Tian Z. Antiapoptotic activity of autocrine interleukin-22 and therapeutic effects of interleukin-22-small interfering RNA on human lung cancer xenografts. Clin Cancer Res. 2008; 14(20):6432-6439. (co-first author).2021,

[4] 陈永艳,Natural Killer Cell-Derived Interferon-Gamma Promotes Hepatocellular Carcinoma Through the Epithelial Cell Adhesion Molecule-Epithelial-to-Mesenchymal Transition Axis in Hepatitis B Virus Transgenic Mice.HEPATOLOGY,2019,69(4):1735-1750.

[5] 陈永艳,陈永艳.CD4+CD25+Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis B Virus Transgenic Mice via Membrane-Bound TGF-beta and OX40.JOURNAL OF INNATE IMMUNITY,2015,8(1):30-42.

专利成果

[1] 魏海明 ,程民,田志刚,陈永艳,一种检测人乳腺球蛋白mRNA表达量的试剂盒及其应用,200710303872.5,2008-07-09,2010-11-03.

科研项目更多

[1] 国家自然科学基金项目；国家传染病重大专项子课题,

[2] TIGIT介导HBV相关肝细胞癌的免疫耗竭及其逆转机制,进行,

[3] 肝硬化脾-肝区域免疫中脾脏单核-巨噬细胞的表型变化及分子调控,进行,

[4] Treg细胞对NK细胞介导的HBV感染肝细胞免疫损伤的调节机制,完成,

[5] 用于研究HBV免疫应答及其致病机理的新型小鼠模型构建与初步应用,进行,

[6] rbT细胞在肝脏天然免疫应答中的作用,进行,

[7] NK/NKT细胞在HBV感染肝细胞癌发生发展中的作用及其分子机制,完成,

[8] 胸腺与免疫细胞发育的分子调控-1,完成,

[9] "自我"天然免疫识别异常介导非可控性肝炎与肝癌转化的分子机制-2,完成,

[10] Poly I:C诱导HBs-Tg小鼠HCC发生发展中NK/NKT细胞的作用及其分子机制,进行,