团队名称：多能量场纳米催化实验室
团队介绍：本科研团队建立于2021年9月，目前已有特任研究员1人，特任副研究员1人，博士后2人，在读博士研究生6人（非全日制1人），在读硕士研究生12人，大四保研生2人，本科生1人（开展毕设），科研助理4人。专注高精尖化学品的纳米催化和生物催化合成。
学生毕业情况：
热烈祝贺2021级专业硕士生2人顺利毕业（团队的首届毕业生）！1人以选调生的身份在山东省地方政府机关单位工作，1人作为工艺工程师PE在中芯国际集成电路制造（上海）工作，祝前程似锦！
团队成员介绍：
李传奇博士主要从事化学/生物医学交叉领域的研究工作，集中在：1）在纳米生物医药方面，针对阿尔兹海默症治疗的医学难点，开发了具有在特定发病位置进行光激活实现治疗的纳米诊疗平台，成功实现了对病兆的特异性治疗；针对肿瘤化疗药物副作用的痛点问题，开发了具有高负载效率的纳米药物平台，实现了对多种抗肿瘤药物高效安全负载。2）在有机功能纳米材料方面，基于超分子原理，开发了一系列能够有效控制组装体结构的分子，并成功用于功能化交联组装体的构筑；进一步，通过模拟天然光捕获体系（Light Harvesting System，LHS）的构筑，设计负载聚集诱导发光分子的交联囊泡，实现了高效人工LHS 的构建，该成果不仅对仿生光捕获的研究有帮助，而且在可调颜色发光、生物示踪成像以及智能传感等领域也有着良好应用前景；为更好的落实产业化前景，成功构筑了简单的荧光分子聚集体实现高效的光捕获体系。3）在生物检测方面，研究重点集中于开发基于新型纳米材料的先进生物传感技术，实现对复杂样品和细胞中生物标志物的高灵敏度和特异性检测。迄今共发表sci 收录论文14 篇，其中以第一作者发表AngewandteChemie International Edition，Advanced Functional Materials, Bioactive Materials 等相关领域权威杂志，入选德国应用化学封面论文并被四川大学发文报道。担任中国化学会会员，作为研究骨干参加多项国家自然科学基金/香港科学基金，作为主要发明人获授权及转让发明专利1 项。
教育背景
09/2016 - 07/2019 四川大学 专业: 生物医学工程 学位: 博士
09/2013 - 07/2016 四川大学 专业：生物化学和分子生物学 学位：硕士
09/2009 - 07/2013 曲阜师范大学 专业：生物工程 学位：学士
工作经历
2020.11-2024.07 香港理工大学 生物医学工程学院 职位：博士后
2024.12-至今 中国科学技术大学苏州高等研究院 职位：特任副研究员
学术论文
1. Chuanqi Li, Jing Zhang, Shiyong Zhang*, Yan Zhao. Efficient Light ‐ Harvesting Systems with Tunable Emission through Controlled Precipitation in Confined Nanospace. Angewandte Chemie International Edition, 2019. 58, 1643-1647. (Q1,IF:18.5)
2. Chuanqi Li, Shiyong Zhang*, Jie Pang, Yao Wu, Zhongwei Gu*, Facile Fabrication of Robust Organic Counterion-Induced Vesicles: Reversible Thermal Behavior for Optical Temperature Sensor and Synergistic Catalyst upon Removal of Amine, Advanced Functional Materials, 2015, 25, 3764-3774. (Q1,IF:16.1)
3. Qin Zhang1, Chuanqi Li1, Bohan Yin, Jiaxiang Yan, Yutian Gu, Yingying Huang, Jiareng Chen, Xinyue Lao, Jianhua Hao, Changqing Yi, Yi Zhou, James Chung Wai Cheung, Siu Hong Dexter Wong*, Mo Yang*. A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer's disease therapy. Bioactive Materials, 2024, 42: 165-177.(Q1,IF:18)
4. Chuanqi Li1 , Jiaxiang Yan1, Bohan Yin, Qin Zhang, Yingying Huang, Jiareng Chen, Fengqi Wang, James Chung Wai Cheung, Mo Yang*, Siu Hong Dexter Wong.* Scaffold-free Efficient Light Harvesting Nanoparticles Based on One-pot Self-Assembly of Donor-Acceptor Aggregation Induced Emission Luminogens. ACS Applied Nano Materials (2024).(Q2,IF:5.9)
5. Jing Zhang, Chuanqi Li, Chunyan Liao, Yunlong Yu, Shiyong Zhang*. Cross-Linked Reverse Vesicle as a General and Effective Vehicle for Hydrophobic Drugs. Langmuir. 2019, 35, 6676-6682.
6. Yongchao Yao, Chuanqi Li, Fangqin Liu, Pengxiang Zhao, Zhongwei Gu, Shiyong Zhang*. Covalent Capture of Supramolecular Species in Aqueous Solution of Water-Miscible Small Organic Molecules. Physical Chemistry Chemical Physics. 2019, 21,10477-10487.
7. Bohan Yin, Qin Zhang, Xinyue Xia, Chuanqi Li, Willis Kwun Hei Ho, Jiaxiang Yan, Yingying Huang, Honglian Wu, Pui Wang, Changqing Yi, Jianhua Hao, Jianfang Wang, Honglin Chen, Siu Hong Dexter Wong, Mo Yang. A CRISPR-Cas12a integrated SERS nanoplatform with chimeric DNA/RNA hairpin guide for ultrasensitive nucleic acid detection. Theranostics, 2022, 12(13), 5914-5930. doi: 10.7150/thno.75816.
8. Bohan Yin, Willis Kwun Hei Ho, Qin Zhang, Chuanqi Li, Yingying Huang, Jiaxiang Yan, Hongrong Yang, Jianhua Hao, Siu Hong Dexter Wong, Mo Yang. Magnetic-Responsive Surface-Enhanced Raman Scattering Platform with Tunable Hot Spot for Ultrasensitive Virus Nucleic Acid Detection. ACS Appl. Mater. Interfaces 2022, 14, 3, 4714–4724.
9. Jiareng Chen, Willis Kwun Hei Ho, Bohan Yin, Qin Zhang, Chuanqi Li, Jiaxiang Yan,Yingying Huang, Jianhua Hao, Changqing Yi, Yu Zhang ,Siu Hong Dexter Wong, Mo Yang. Magnetic-responsive upconversion luminescence resonance energy transfer (LRET) biosensor for ultrasensitive detection of SARS-CoV-2 spike protein. Biosensors and Bioelectronics, Volume 248, 15 March 2024, 115969.
10. Qin Zhang, Bohan Yin, Jianhua Hao, Linjie Ma, Yingying Huang, Xueying Shao, Chuanqi Li, Zhiqin Chu, -Changqing Yi, Siu Hong Dexter Wong, Mo Yang, An AIEgen/graphene oxide nanocomposite (AIEgen@GO)-based two-stage “turn-on” nucleic acid biosensor for rapid detection of SARS-CoV-2 viral sequence, Aggregate, 2023, 4, e195.
11. Bohan Yin, Qin Zhang, Jiaxiang Yan, Yingying Huang, Chuanqi Li, Jiareng Chen, Chunyi Wen, Siu Hong Dexter Wong, Mo Yang. Nanomanipulation of Ligand Nanogeometry Modulates Integrin/Clathrin-Mediated Adhesion and Endocytosis of Stem Cells. Biosensors and Bioelectronics, Nano Lett. 2023, 23, 19, 9160–9169.
12. Qin Zhang, Bohan Yin, Yingying Huang, Yutian Gu, Jiaxiang Yan, Jiareng Chen, Chuanqi Li, Yu Zhang, Siu Hong Dexter Wong, Mo Yang. A dual 'turn-on' biosensor based on AIE effect and FRET for in situ detection of miR-125b biomarker in early Alzheimer's disease. Biosensors and Bioelectronics, Volume 230, 15 June 2023, 115270.
13. Yingying Huang, Qin Zhang, Ching Ying Katherine Lam, Chuanqi Li, Chen Yang, Zhiming Zhong, Ruolin Zhang, Jiaxiang Yan, Jiareng Chen, Bohan Yin, Siu Hong Dexter Wong, Mo Yang, An Aggregation-Induced Emission-Based Dual Emitting Nanoprobe for Detecting Intracellular pH and Unravelling Metabolic Variations in Differentiating Lymphocytes, ACS Nano 2024, 18, 24, 15935–15949.
14. Qian Zhang, Yun Chen, Ruilin Lu, Yongchao Yao, Chuanqi Li, Yunlong Yua, Shiyong Zhang, Cross-linked small-molecule capsules with excitation wavelength-dependent photoluminescence and high loading capacity: design, synthesis and application in imaging-guided drug delivery, Journal of Materials Chemistry B, Issue 13, 2020.
专利
1. 张仕勇、李传奇、张静。具有疏水腔体的硫辛酸纳米胶囊的制备与应用。【国家发明专利CN110302175B，已转让】