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特任副研究员

Paper Publications

Liang, L.-J.#, Wang, Y.#, Hua, X.#, et al. Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time-Resolved Monitoring of Substrate Ubiquitination in Live Cells. JACS Au 2023, DOI: 10.1021/jacsau.3c00421.
Liang, L.-J. #, Chu, G.-C. #, Qu, Q. #, Zuo, C., Mao, J.-X, Zheng, Q.-Y, Chen, J.-N, Meng, X.-B, Jing, Y.-W, Deng, H.-T, Li, Y.-M., Liu, L. Chemical Synthesis of Activity-Based E2-Ubiquitin Probes for the Structural Analysis of E3 Ligase-Catalyzed Transthiolation. Angew. Chem. Int. Ed. 60, 2021, 17171-17177..
Pan, M.#, Zheng, Q. -Y. #, Wang, T. #, Liang, L. -J #, Mao, J.-X, Zuo, C., Ding, R.-C, Ai, H.-S, Xie, Y., Si, D., Yu, Y.-Y, Liu, L., Zhao, M-L. Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature. 600, 2021, 334-338..
Liang, L.-J., Si, Y.-Y, Tang, S., Huang, D.-L, Wang, Z.A., Tian, C.-L, Zheng, J.-S. Biochemical properties of K11,48-branched ubiquitin chains. Chin. Chem. Lett. 29, 2018, 1155-1159.
Zhang, Z.-Q., Yang, C.-T., Liang, L.-J., Xiao, B., Lu, X., Liu, J.-H., Sun, Y.-Y., Marder, T.B., Fu, Y. Copper-catalyzed/promoted cross-coupling of gem -diborylalkanes with nonactivated primary Alkyl halides: An alternative route to alkylboronic esters. Org. Lett. 16, 2014, 6342-6345.
Tan, X.-L., Pan, M., Zheng, Y., Gao, S., Liang, L.-J., Li, Y.-M. Sortase-mediated chemical protein synthesis reveals the bidentate binding of bisphosphorylated p62 with K63 diubiquitin. Chem. Sci. 8, 2017, 6881-6887.
Si, Y.-Y., Liang, L.-J., Tang, S., Qi, Y.-K., Huang, Y.-C, Zheng, J.-S. One-pot ligation strategy for atypical ubiquitin chains synthesis by using the trifluoroacetamidomethyl-protected isopeptide-linked Ub (Tfacm-isoUb) unit. Tetrahedron Lett. 59, 2018, 268-271.
Si, Y.-Y., Liang, L.-J., Tang, S., Qi, Y.-K, Huang, Y.-C, Liu, L. Semi-synthesis of disulfide-linked branched tri-ubiquitin mimics. Sci. China Chem. 61, 2018, 412-417.
Tang, S. #, Liang, L.-J. #, Si, Y.-Y. #, Gao, S., Wang, J.-X., Liang, J., Mei, Z., Zheng, J.-S., Liu, L. Practical Chemical Synthesis of Atypical Ubiquitin Chains by Using an Isopeptide-Linked Ub Isomer. Angew. Chem. Int. Ed. 56, 2017, 13333-13337.
Pan, M. #, Zheng, Q.-Y #, Ding, S. #, Zhang, L., Qu, Q., Wang, T., Hong, D., Ren, Y.-X, Liang, L.-J, Chen, C.-L, Mei, Z., Liu, L. Chemical Protein Synthesis Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains. Angew. Chem. Int. Ed. 58, 2019, 2627-2631.
Lu, L.-N, Guo, Y., Wang, T., Liang, L.-J, Zhao, S., Wang, F., Liu, L. Inactivity of YGL082W in vitro due to impairment of conformational change in the catalytic center loop. Sci. China Chem. 63,2020, 237-243.
Sui, X., Wang, Y., Du, Y.-X., Liang, L.-J., Zheng, Q.-Y, Li, Y.-M., Liu, L. Development and application of ubiquitin-based chemical probes. Chem. Sci. 11, 2020, 12633-12646.

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