中文

李丰银

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Degree:Dr

Basic Information
Scientific Research

Profile

Dr. Li received his Ph.D. degree in Biochemistry and Molecular Biology from China Agricultural University in 2013. Subsequently he worked as a Postdoctoral Research Scholar (2013.8-2018.9), and was promoted as Assistant Research Scientist (2018.9-2019.10) at the Department of Microbiology and Immunology, Medical School, the University of Iowa, USA. He joined the School of Life Sciences of University of Science and Technology of China (USTC) a. His research work is committed to explore the regulatory mechanism of T cells development and its anti-infection immunity. Dr. Li systematically studied the roles of transcription factor Tcf1 and its homolog Lef1 in early T cells fate decision and mature T cells subsets specification in response to antigen infection. His research work has been widely recognized by the international researchers in the related field.

Educational Experience

[1] 2021.9~2021.9， l2021.01--至今，中国科学技术大学，生命科学与医学部，教授

[2] 2021.9~2021.9， l2013.08--2018.09，美国爱荷华大学，医学院，博士后

[3] 2021.9~2021.9， l2010.09--2013.06，中国农业大学，生物学院，博士

Work Experience

[1] 2021.9~2021.9， 2020.03--2021.01，中国科学技术大学，生命科学与医学部，特任研究员

[2] 2021.9~2021.9， 2018.09--2019.10，美国爱荷华大学，医学院，助理研究科学家

Research Focus

[1] 参与抗病毒感染以及肿瘤中T淋巴细胞的转录与表观遗传调控机制

[2] 常见自身免疫性疾病的发病机理以及药物研发的生物学基础

[3] 髓系和淋巴系胸腺T淋巴细胞早期谱系分化的机制研究及与白血病等重大疾病的关系

PapersMore

[1] 16. Youn Soo Choi#, Jodi A Gullicksrud#, Shaojun Xing, Zhouhao Zeng, Qiang Shan, Fengyin Li, Paul E Love, Weiqun Peng, Hai-Hui Xue*, Shane Crotty*.(2015). LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6. Nat Immunol 16, 980-990..2021,

[2] 15. Qi Yang, Fengyin Li, Christelle Harly, Shaojun Xing, Longyun Ye, Xuefeng Xia, Haikun Wang, Xinxin Wang, Shuyang Yu, Xinyuan Zhou, Maggie Cam, Hai-Hui Xue*, Avinash Bhandoola*. (2015). TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol 16, 1044-1050..2021,

[3] 14. Shaojun Xing, Peng Shao, Fengyin Li, Xudong Zhao, WooseokSeo, Justin C. Wheat, Selvi Ramasamy, Jianfeng Wang, Xiang Li, Weiqun Peng, Shuyang Yu, Chengyu Liu, Ichiro Taniuchi, David A. Sweetser, Hai-Hui Xue*. (2018). Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity. J Exp Med 8, 2211-2226..2021,

[4] 13. Yan Xiu, Qianze Dong, Qingchang Li, Fengyin Li, Nick Borcherding, Weizhou Zhang, Brendan Boyce, Hai-hui Xue*, Chen Zhao*. (2018). Stabilization of NF-KB-inducing kinase suppresses MLL-AF9–induced acute myeloid leukemia. Cell reports 2, 350-358..2021,

[5] 7. Yue Zhang#, Fengyin Li#, Yongli Song, Xiaole Sheng, Kai Xiong, Lei Chen, Dequan Liu, Christopher Lengner, Lixiang Xue, Zhengquan Yu*. (2016). Numb and Numbl act to determine mammary myoepithelial cell fate,maintain epithelial identity, and support lactogenesis. FASEB J 30, 3474-3488..2021,

[6] 6. Shuyang Yu#, Fengyin Li#, Shaojun Xing, Tianyan Zhao, Weiqun Peng, Hai-Hui Xue*. (2016). Hematopoietic and Leukemic Stem Cells Have Distinct Dependence onTcf1 and Lef1 Transcription Factors. J Biol Chem 291, 11148-11160..2021,

[7] 5. Cong Lv#, Fengyin Li#, Xiang Li#, Yuhua Tian#, Yue Zhang, Xiaole Sheng, Yongli Song, Qingyong Meng, Shukai Yuan, Liming Luan, Thomas Andl, XuFeng, Baowei Jiao, Mingang Xu, Maksim V. Plikus, Xing Dai, ChristopherLengner, Wei Cui, Fazheng Ren, Jianwei Shuai, Sarah E. Millar, Zhengquan Yu*. (2017). MiR-31 promotes mammary stem cell expansion and breast tumorigenesisby suppressing Wnt signaling antagonists. Nat Commun 8, 1-18..2021,

[8] 4. Fengyin Li, Zhouhao Zeng, Shaojun Xing, Jodi A. Gullicksrud, Qiang Shan, Jinyong Choi, Vladimir P. Badovinac, Shane Crotty, Weiqun Peng & Hai-Hui Xue*. (2018). Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun 9, 1-18..2021,

[9] 2. Fengyin Li, Bing He, Xiaoke Ma, Shuyang Yu, Rupali R. Bhave, Steven R. Lentz, Kai Tan, Monica L. Guzman, Chen Zhao*, Hai-Hui Xue*. (2017). Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1. Cell Stem Cell, 21, 1-15..2021,

[10] 1. Fengyin Li*, Xin Zhao#, Yali Zhang, Peng Shao, Xiaoke Ma, William J. Paradee, Chengyu Liu, Jianmin Wang, and Hai-Hui Xue*. (2021). TFH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function. PNAS, 118, e2014562118..2021,

Research Project

[1] 中国科学技术大学引进人才启动经费,600,

[2] 转录因子Tcf1通过约束T细胞共抑制通路保护TFH细胞生物学功能的分子机制,58,2021-01至2024-12,

[3] 获得性免疫应答，国家自然科学基金优秀青年基金项目,120,2021-01至2023-12,

[4] 获得性免疫应答,进行,

[5] 转录因子Tcf1通过约束T细胞共抑制通路保护Tfh细胞生物学功能的分子机制,进行,

[6] Wnt信号通路共抑制分子Tle调控小鼠造血干细胞的机理研究,进行,

[7] 抗感染与炎症中CD4+TFH淋巴细胞的转录与表观遗传调控,进行,