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  • 特任研究员
  • 博士生导师
  • 硕士生导师
  • 教师拼音名称:Lv Xinyou
  • 电子邮箱:
  • 学历:研究生(博士后)
  • 办公地点:南区人文与社会科学学院203
  • 学位:博士
  • 毕业院校:浙江大学
论文成果
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Retrieval-extinction of drug memory requires AMPA receptor trafficking
  • 影响因子:14.957
  • DOI码:10.1126/sciadv.add6642
  • 发表刊物:Science Advances
  • 摘要:Disruption of drug-associated memory reduces relapse. Transient memory retrieval facilitates the upcoming extinction of addiction memory, while the neural basis for this beneficial outcome remains unelucidated. Here, we report that AMPA receptor trafficking acts as the central component for retrieval-extinction-based drug memory intervention. Drug memory retrieval transiently reduces AMPA receptor-mediated synaptic transmission in prefrontal cortical neurons (lasting for 2 to 4 hours) through rapid removal of calcium-permeable AMPA receptors from the synapse, which returned to basal state level after 6 hours. The receptor trafficking is orchestrated by dopamine D1 but not D2 receptor signaling. Blocking AMPA receptor trafficking abolishes retrieval-extinction-mediated addiction memory degradation. These results reveal the molecular mechanism underlying the efficacy of transient memory retrieval on helping to erase addiction memory and support targeting the prefrontal cortex to reduce relapse (e.g., with noninvasive brain stimulation).
  • 论文类型:期刊论文
  • 卷号:8
  • 期号:51
  • 是否译文:
  • 发表时间:2022-12-23
  • 收录刊物:SCI