Scientific Research

Research Field

1. Roles of three-dimensional transcriptional regulation of lncRNAs and 3D genome structure in brain aging.

2. Transcriptional regulation of lncRNAs and higher order chromatin structures in spermatogenesis.

Paper Publications

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• piR-36249 and DHX36 together inhibit testicular cancer cells progression by upregulating OAS2..Noncoding RNA Research,2023,8(2):174-186.
• Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress..iScience,2022,26(1):
• The landscape of aging..Science China. Life sciences,65(12):2354-2454.
• Stub1 maintains proteostasis of master transcription factors in embryonic stem cells..Cell Reports,2022,39(10):
• NicE-C efficiently reveals open chromatin-associated chromosome interactions at high resolution..Genome Research,32(3):534-544.
• The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum..Cell Death & Differentiation,28(9):2634-2650.

Patents

• Xiaoyuan Song,Zhang Ran,luozhengyu,hutengfei,Invent,NicE-C technique for detecting chromatin interactions between chromatin open sites,202110773743.2,2021-07-08,2021-10-22,

Published Books

• Xiaoyuan Song,Jun Cao,Find the life code.[Popular Science].USTC Press,2020-07-01

Research Projects

• Interaction between tumor cells and immune microenvironment and transcriptional regulation mechanism in malignant tumors,
• High-resolution study of three-dimensional spatial structure of chromatin during meiotic homologous recombination,
• The regulatory function and mechanism of long non-coding RNA on learning and memory-related genes during brain aging,
• Function and regulatory mechanism of LncRNA and interaction complex in spermatogenesis-1,