王剑
1. 疾病相关T细胞表型和功能的鉴定
2. 疾病相关T细胞抗原表位的筛选,阐释T细胞介导的疾病的发病机制
3. 基于抗原表位和T细胞受体(TCR)的疾病治疗,如多肽疫苗、mRNA疫苗和TCR-T等
- Naghavian R, Faigle W, Oldrati P, Wang J, Toussaint NC, Qiu Y, Medici G, Wacker M, Freudenmann LK, Bonté PE, Weller M, Regli L, Amigorena S, Rammensee HG, Walz JS, Brugger SD, Mohme M, Zhao Y, Sospedra M, Neidert MC, Martin R. Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma. Nature. 2023 May;617(7962):807-817..
- Wang J, Weiss T, Neidert MC, Toussaint NC, Naghavian R, Sellés Moreno C, Foege M, Tomas Ojer P, Medici G, Jelcic I, Schulz D, Rushing E, Dettwiler S, Schrörs B, Shin JH, McKay R, Wu CJ, Lutterotti A, Sospedra M, Moch H, Greiner EF, Bodenmiller B, Regli L, Weller M, Roth P, Martin R. Vaccination with Designed Neopeptides Induces Intratumoral, Cross-reactive CD4+ T-cell Responses in Glioblastoma. Clin Cancer Res. 2022 Dec 15;28(24):5368-5382..
- Wang J, Jelcic I, Mühlenbruch L, Haunerdinger V, Toussaint N, Zhao Y, Cruciani C, Faigle W, Naghavian R, Foege M, Binder T, Eiermann T, Opitz L, Fuentes-Font L, Reynolds R, Kwok W, Nguyen J, Lee J, Lutterotti A, Münz C, Rammensee H, Hauri-Hohl M, Sospedra M, Stevanovic S, and Martin R (2020). HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis. Cell 183(5):1264-1281 e20..
- Jelcic I*, Al Nimer F*, Wang J, Lentsch V, Planas R, Jelcic I, Madjovski A, Ruhrmann S, Faigle W, Frauenknecht K, Pinilla C, Santos R, Hammer C, Ortiz Y, Opitz L, Grönlund H, Rogler G, Boyman O, Reynolds R, Lutterotti A, Khademi M, Olsson T, Piehl F, Sospedra M, and Martin R (2018). Memory B Cells Activate Brain-Homing, Autoreactive CD4(+) T Cells in Multiple Sclerosis. Cell 175, 85-100 e123. (*Co-first author).
- Wang J, Li F, Sun R, Gao X, Wei H, and Tian Z (2014). Klebsiella pneumoniae alleviates influenza-induced acute lung injury via limiting NK cell expansion. J Immunol 193, 1133-1141..
- Wang J*, Li F*, Sun R, Gao X, Wei H, Li L, and Tian Z (2013). Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages. Nat Commun 4, 2106. (*Co-first author).
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