姚东宝，中国科大化学与材料科学学院副教授，硕士生导师。1989年生，山东费县人。2012年6月毕业于济南大学高分子材料与工程专业，获工学学士学位；2017年11月毕业于中国科大高分子科学与工程系，获理学博士学位（导师：梁好均 教授）；2016年9月至2017年9月，受国家留学基金委资助于美国得州大学奥斯汀分校分子生物科学系进行联合培养（导师：Andrew D. Ellington 教授）。博士毕业后留校从事博士后研究工作（合作导师：梁好均 教授）；2020年8月加入中国科大化学与材料科学学院高分子科学与工程系，任特任副研究员；2025年4月至今，任中国科大化学与材料科学学院化学系副教授。

研究方向：

研究方向为核酸组装与分子器件。通过理性化设计精准、可编程性核酸自组装反应网络，推动其在纳米粒子超晶格组装材料、DNA逻辑运算、pH响应性功能核酸器件、核酸比色检测、核酸自组装网络介导的CRISPR/dCas9基因转录调控等方面的发展及相关应用。

科研概况：

近年来，发表 SCI 论文 40 余篇，其中以第一/通讯作者（含共同）身份在Nat. Rev. Methods Primers、PNAS（2篇）、JACS（3篇）、Angew. Chem.、ACS Nano（2篇）、Nano Lett.、Sci. China Chem.等重要学术期刊发表论文20余篇。曾获2017年度中国科学院院长优秀奖；入选2018年度博士后创新人才支持计划，项目成果“DNA分子机器调控胶体结晶自组装”获评2020年度博士后创新人才支持计划优秀创新成果；获中国科大“墨子杰出青年特资津贴”一等资助。主持国家自然科学基金青年科学基金和面上项目、中国科大青年创新重点基金、博士后科学基金面上项目等科研项目。

发表论文：

1. Bárbara B Mendes#, João Conniot#, Aviram Avital#, Dongbao Yao#, Xingya Jiang#, Xiang Zhou#, Noga Sharf-Pauker#, Yuling Xiao#, Omer Adir#, Haojun Liang*, Jinjun Shi*, Avi Schroeder*, João Conde*, Nanodelivery of nucleic acids. Nature Reviews Methods Primers 2022, 2 (1), 24.

2. Dongbao Yao#,*, Yunhan Zhang#, Xiang Zhou#,*, Xiaoyun Sun, Xiaoyu Liu, Junxiang Zhou, Wei Jiang, Wenqiang Hua*, Haojun Liang*, Catalytic-assembly of programmable atom equivalents. Proceedings of the National Academy of Sciences 2023, 120 (18), e2219034120.

3. Xiang Zhou#, Dongbao Yao#,*, Wenqiang Hua, Ningdong Huang, Xiaowei Chen, Liangbin Li, Miao He, Yunhan Zhang, Yijun Guo, Shiyan Xiao*, Fenggang Bian*, Haojun Liang*, Programming Colloidal Bonding Using DNA Strand-Displacement Circuitry. Proceedings of the National Academy of Sciences 2020, 117 (11), 5617-5623.

4. Xiaoyun Sun#, Wenqiang Hua#, Xiaoyu Liu, Jing Jin, Jianing Zhang, Jie Tian, Bin Zheng, Wei Jiang, Dongbao Yao*, Haojun Liang, Programming Supercrystals Using DNA-Functionalized Colloids That Can Replicate Themselves. Angewandte Chemie International Edition 2024, 63 (22), e202403492.

5. Xiaoyu Liu#, Dongbao Yao#,*, Yun Wang, Dian Ni, Wenqiang Hua,*, Jie Tian, Liulin Yang, Haixin Lin, Haojun Liang, Zhaoxiang Deng*, Implementation of Digital Computing by Colloidal Crystal Engineering with DNA. Journal of the American Chemical Society 2024, 146 (44), 30573-30583.

6. Miao He#, Xiang Zhou#,*, Zhigang Li, Xue Yin, Wenjie Han, Junxiang Zhou, Xiaoyun Sun, Xiaoyu Liu, Dongbao Yao*, Haojun Liang*, Programmable Transcriptional Modulation with a Structured RNA-Mediated CRISPR-dCas9 Complex. Journal of the American Chemical Society 2022, 144 (28), 12690-12697.

7. Dongbao Yao#, Tingjie Song#, Xianbao Sun, Shiyan Xiao*, Fujian Huang, Haojun Liang*, Integrating DNA-Strand-Displacement Circuitry with Self-Assembly of Spherical Nucleic Acids. Journal of the American Chemical Society 2015, 137 (44), 14107-14113.

8. Dongbao Yao, Sanchita Bhadra, Erhu Xiong, Haojun Liang, Andrew D Ellington*, Cheulhee Jung*, Dynamic Programming of a DNA Walker Controlled by Protons. ACS Nano 2020, 14 (4), 4007-4013.

9. Yijun Guo#, Dongbao Yao#,*, Bin Zheng, Xianbao Sun, Xiang Zhou, Bing Wei, Shiyan Xiao, Miao He, Chengxu Li, Haojun Liang*, pH-Controlled Detachable DNA Circuitry and Its Application in Resettable Self-Assembly of Spherical Nucleic Acids. ACS Nano 2020, 14 (7), 8317-8327.

10. Xiaoyun Sun#, Dongbao Yao#,*, and Haojun Liang*, pH-Controlled Resettable Modular DNA Strand-Displacement Circuits. Nano Letters 2023, 23 (24), 11540-11547.

11. Xiang Li#, Dongbao Yao#,*, Junxiang Zhou, Xiang Zhou, Xianbao Sun, Bing Wei, Chengxu Li, Bin Zheng, Haojun Liang*, Cascaded DNA Circuits-Programmed Self-Assembly of Spherical Nucleic Acids for High Signal Amplification. Science China Chemistry 2020, 63, 92-98.

12. Bing Wei#, Dongbao Yao#,*, Bin Zheng, Xiang Zhou, Yijun Guo, Xiang Li, Chengxu Li, Shiyan Xiao, Haojun Liang*, Facile Strategy for Visible Disassembly of Spherical Nucleic Acids Programmed by Catalytic DNA Circuits. ACS Applied Materials & Interfaces 2019, 11 (12), 19724-19733.

13. Wenjie Han, Miao He, Yunhan Zhang, Junxiang Zhou, Zhigang Li, Xiaoyu Liu, Xiaoyun Sun, Xue Yin, Dongbao Yao*, Haojun Liang*, Cadherin-dependent adhesion modulated 3D cell-assembly. Journal of Materials Chemistry B 2022, 10 (26), 4959-4966.

14. Bin Zheng*, Huaze Dong, Jinmiao Zhu, Qi Zhang, Shiwei Yang, Dongbao Yao*, A rational design of a cascaded DNA circuit for nanoparticle assembly and its application in the discrimination of single-base changes. Journal of Materials Chemistry B 2022, 10 (24), 4561-4567.

15. Dongbao Yao, Shiyan Xiao*, Xiang Zhou, Hui Li, Bei Wang, Bing Wei, Haojun Liang*, Stacking Modular DNA Circuitry in Cascading Self-Assembly of Spherical Nucleic Acids. Journal of Materials Chemistry B 2017, 5 (31), 6256-6265.

16. Dongbao Yao, Hui Li, Yijun Guo, Xiang Zhou, Shiyan Xiao*, Haojun Liang*, A pH-Responsive DNA Nanomachine-Controlled Catalytic Assembly of Gold Nanoparticles. Chemical Communications 2016, 52 (48), 7556-7559.

17. Junxiang Zhou#, Miao He#, Xue Yin, Yue Yu*, Dongbao Yao*, Haojun Liang*, Unexploited Performance of NLS in the dCas9-VPR-Mediated Transcriptional Activation. ACS Chemical Biology 2023, 18 (5), 1246-1253.

18. Dongbao Yao, Bei Wang, Shiyan Xiao*, Tingjie Song, Fujian Huang, Haojun Liang*, What Controls the “Off/on Switch” in the Toehold-Mediated Strand Displacement Reaction on DNA Conjugated Gold Nanoparticles? Langmuir 2015, 31 (25), 7055-7061.

19. Xiang Zhou#, Dongbao Yao#, Miao He, Shiyan Xiao*, Haojun Liang*, Optimizing the Toehold Strategy of On-Chip Nucleic Acid Hybridization Probe for the Discrimination of Single Nucleotide Polymorphism. Langmuir 2018, 34 (49), 14811-14816.

20. Dongbao Yao, Tingjie Song, Bin Zheng*, Shiyan Xiao, Fujian Huang, Haojun Liang*, The Combination of Gold Nanorods and Nanoparticles with DNA Nanodevices for Logic Gates Construction. Nanotechnology 2015, 26 (42), 425601.

21. Yijun Guo, Bing Wei, Xiang Zhou, Dongbao Yao*, Haojun Liang*, DNA Walker-Programmed Nanoparticle Superlattice. Acta Chimica Sinica 2021, 79 (2), 192-199.

22. Xue Yin, Dongbao Yao*, Haojun Liang*, Tuning Gene Expression by Hairpin Elements near the Start Codon of mRNA in Mammalian Cells. Chinese Journal of Chemical Physics 2022, 36 (6), 755-763.

23. Xue Yin, Dongbao Yao*, Haojun Liang*, Shortening Pairing of the 3' Tail of shRNA with Target mRNA Reduces the Off-Target Effect. Journal of Functional Polymers 2023, 36 (3), 310-320.

(#共同第一作者，*通讯作者)

授权专利：

1. 梁好均; 姚东宝; 肖石燕; 宋廷结; 一种DNA催化循环网络诱导的DNA-纳米金组装方法及其在单碱基突变检测中的应用, 2017-8-29, 中国, ZL 2015 1 0350472.4.

2. 梁好均; 周翔; 姚东宝; 一种DNA催化网络调控的纳米粒子结晶的方法, 2024-3-29, 中国, ZL 2020 1 0122120.4.

ResearchGate: https://www.researchgate.net/profile/Dongbao-Yao-2?ev=hdr_xprf

Google Scholar: https://scholar.google.com/citations?hl=zh-CN&user=d1H_I3UAAAAJ