张亮，现任中国科学技术大学精准智能化学全国重点实验室特任研究员及博士生导师。2019年，他在武汉大学高等研究院获得博士学位，师从邓鹤翔教授；随后于2019年至2021年在武汉大学口腔医学院孙志军教授团队进行博士后研究，2021年至2025年在香港科技大学唐本忠院士团队继续从事博士后研究。2025年3月获得中科院百人计划资助。他的研究方向聚焦于人工智能辅助的光学功能晶态多孔材料（如MOF、COF、HOF、Cage等）的精准智能创制，并探索其在生命健康及能源转换等领域的应用。他致力于发展化学家与人工智能机器科学家相结合的新型化学研究范式，以突破传统“试错”模式，加速高性能光学功能晶态多孔材料的精准智能化研发。目前以第一/通讯作者身份在Nat. Chem. (1), Nat. Rev. Chem. (1), Nat. Commun. (3), J. Am. Chem. Soc. (2), Angew. Chem. Int. Ed. (2), Adv. Mater. (3), Chem (1), Matter (1), Adv. Funct. Mater. (3), Nano Letter (2), Bioact. Mater. (1), Aggregate (1), Green Energy & Environment (1) 等期刊上发表论文20余篇。近年主持了中国科学院率先行动“百人计划”项目、国家自然科学青年基金项目 C 类、中国博士后面上和特别资助项目各一项，作为骨干成员参与了香港及内地多项基金。担任《Exploration》期刊的青年编委。
主要研究兴趣
人工智能（AI）赋能光学功能晶态多孔材料（MOF、COF、HOF等）的精准智能创制，并探索它们在光电显示、生命健康、催化、能源转换等领域的应用。
主要研究方向
1.精准化、智能化双驱动的AIE COF材料的精准智能创制及机制研究。
2. AI助力优异光物理性质（如光致、电致、压致、力致发光、室温磷光及多光子荧光等）晶态多孔材料精准智能合成。
3. AI助力功能和应用导向的MOF、COF、HOF等材料的个性化定制、规模化、标准化、大批量制备及其在光电显示、生命健康、催化、能源转换等领域的应用。
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代表论文
1. Liang Zhang*, Jun Jiang* Carbon capture with COFs, Nat. Rev. Chem. 2026, accepted.
2. Liang Zhang†, Jiahui Du†, Zikai Xie†, Linjiang Chen*, Wenlang Li, Weihang Geng, Yi Zhou, Xinwen Ou, Chengtao Gong, Yijun Gao, Shan He, Chunxing Yan, Chengbin Zhao, Yantian Jiao, Sengyi Yang, Bing Huang, Jacky W. Y. Lam, Jun Qian, Jun Jiang*, Ben Zhong Tang*, Hexiang Deng*, “Discovering covalent organic frameworks by AI-assisted interactive experiment-learning evolution” Nat. Chem. 2025, 17, 1645-1654.
3. Liang Zhang†,*, Weihang Geng†, Xinwen Ou†, Shan He†, Xiao-Hang He, Wenlang Li, Yantian Jiao, Yi Zhou, Chensen Li, Yingying Chen, Wutong Du, Ziyi Cheng, Ziyi Jin, Jacky W. Y. Lam*, Jun Qian*, Ben Zhong Tang*, “Boosting the Brightness of Covalent Organic Frameworks by Integration of Dual-Docking Luminogens with Aggregation-Induced Emission Effect” J. Am. Chem. Soc. 2025, 147, 39999-40009.
4. Liang Zhang†,*, Weihang Geng†, Xinwen Ou†, Shan He†, Xiao-Hang He, Wenlang Li, Yantian Jiao, Ziyi Cheng, Ziyi Jin, Jun Qian*, Ben Zhong Tang*, “Boosting the brightness of aggregation-caused quenching chromophore-based covalent organic frameworks via energy level matching strategy” Nat. Commun. 2025, 16, 9991.
5. Sheng-Yi Yang†, Liang Zhang†, Fan-Cheng Kong†, Yingying Chen†, Wei-Jian Li, Fei Wang, Cheng Liu, Xuan He, Xuedong Xiao, Jin Wang, Jianwei Sun, Philip C. Y. Chow*, Ryan T. K. Kwok*, Jacky W. Y. Lam*, Ben Zhong Tang*, “Scintillators with Aggregation-Induced Emission” Chem 2025, 11, 5, 102534.
6. Liang Zhang†, Shuo Wang†, Qi-Chao Yang†, An Song, Yuan-Yuan Wang, Wen-Da Wang, Meng-Jie Zhang, Hao Li, Zhi-Jun Sun*, Hexiang Deng*, “Bimetallic Covalent Organic Framework Trigger PANoptosis for Efficient Radiotherapy” Adv. Mater. 2025, 37, 2413002.
7. Liang Zhang†, Boxin Zhang†, Meng-Jie Zhang†, Wenlang Li, Hao Li, Yantian Jiao, Qi-Chao Yang, Shuo Wang, Yuan-Tong Liu, An Song, Hai-Tao Feng, Jianwei Sun, Ryan T. K. Kwok, Jacky W. Y. Lam*, Ben Zhong Tang*, Zhi-Jun Sun*, “Trigger Inducible Tertiary Lymphoid Structure Formation using Covalent Organic Frameworks for Cancer Immunotherapy” Nat. Commun. 2025, 16, 1-14.
8. Qi-Chao Yang, Yuan-Yuan Wang, Shuo Wang, An Song, Wen-Da Wang, Liang Zhang*, Zhi-Jun Sun*, “Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy” Bioact. Mater. 2025, 47, 283-294.
9. Liang Zhang†, An Song†, Qi-Chao Yang, Shu-Jin Li, Shuo Wang, Shu-Cheng Wan, Jianwei Sun, Ryan T. K. Kwok, Jacky W. Y. Lam*, Hexiang Deng*, Ben Zhong Tang*, Zhi-Jun Sun*, “Integration of AIEgens into Covalent Organic Frameworks for Pyroptosis and Ferroptosis Primed Cancer Immunotherapy” Nat. Commun. 2023, 14, 5355.
10. Liang Zhang†, Fuding Guo†, Saiting Xu, Qiang Deng, Mengjie Xie, Jianwei Sun, Ryan T. K. Kwok, Jacky W. Y. Lam, Hexiang Deng*, Hong Jiang*, Lilei Yu* Ben Zhong Tang*, “AIEgen-based Covalent Organic Frameworks for Preventing Malignant Ventricular Arrhythmias Via Local Hyperthermia Therapy” Adv. Mater. 2023, 35, 2304620.
11. Liang Zhang†, Shu-Cheng Wan†, Jianyu Zhang†, Meng-Jie Zhang, Qi-Chao Yang, Boxin Zhang, Wu-Yin Wang, Jianwei Sun, Ryan T. K. Kwok, Jacky W. Y. Lam*, Hexiang Deng*, Zhi-Jun Sun*, Ben Zhong Tang*, “Activation of Pyroptosis Using AIEgen-Based sp2 Carbon-Linked Covalent Organic Frameworks” J. Am. Chem. Soc. 2023, 145, 17689-17699.
12. Liang Zhang†, Qi-Chao Yang†, Shuo Wang, Yao Xiao, Shu-Cheng Wan, Hexiang Deng*, Zhi-Jun Sun*, “Engineering Multienzyme-Mimicking Covalent Organic Frameworks as Pyroptosis Inducers for Boosting Antitumor Immunity” Adv. Mater. 2022, 34, 2108174.
13. Liang Zhang†, Yi Zhou†, Mei Jia†, Yiwen He, Wei Hu, Qi Liu, Jing Li, Xiaohui Xu, Chao Wang, Anna Carlsson, Sorin Lazar, Arno Meingast, Yanhang Ma, Jun Xu, Wen Wen, Zhihong Liu, Jun Cheng, Hexiang Deng*, “Covalent Organic Framework for Efficient Two-Photon Absorption” Matter 2020, 2, 1049-1063.
14. Liang Zhang†, Shibo Wang†, Yi Zhou, Chao Wang, Xian-Zheng Zhang, Hexiang Deng*, “Covalent Organic Frameworks as Favorable Constructs for Photodynamic Therapy” Angew. Chem. Int. Ed. 2019, 58, 14213-14218.
15. Yanqiu Duan†, Yang Yu†, Peilai Liu†, Yao Gao, Xinyue Dai, Liang Zhang*, Liang Chen*, Yu Chen*, “Reticular Chemistry-Enabled Sonodynamic Activity of Covalent Organic Frameworks for Nanodynamic Cancer Therapy” Angew. Chem. Int. Ed. 2023, 62, e202302146.
16. Liang Zhang†, Yao Xiao†, Qi-Chao Yang, Lei-Lei Yang, Shu-Cheng Wan, Shuo Wang, Lu Zhang,* Hexiang Deng, Zhi-Jun Sun* “Staggered Stacking Covalent Organic Frameworks for Boosting Cancer Immunotherapy” Adv. Funct. Mater. 2022, 32, 2201542.
17. Liang Zhang†, Lei-Lei Yang†, Qi-Chao Yang, Shu-Cheng Wan, Yao Xiao, Hexiang Deng*, Zhi-Jun Sun*, “3D Covalent Organic Frameworks with Cross-linked Pores for Efficient Cancer Immunotherapy” Nano. Lett. 2021, 21, 7979-7988.
18. Boxin Zhang†, Liang Zhang†, Wuyin Wang, Enli Yang, An Song, Dian Xiong, Qi-chao Yang, Hexiang Deng*, Zhi-Jun Sun* “Single-Cell RNA-Sequencing-Aided Covalent Organic Frameworks-Based Microneedle Design Targeting Phototherapy Resistant Tumor Cell” Adv. Funct. Mater. 2024, 34, 2313890.
19. Liang Zhang†, Lezhi Yi†, Zhi-Jun Sun, Hexiang Deng*, “Covalent organic frameworks for optical applications” Aggregate. 2021, 2, e24.
20. Lei-Lei Yang†, Liang Zhang†, Shu-Cheng Wan, Shuo Wang, Zhi-Zhong Wu, Qi-Chao Yang, Yao Xiao, Hexiang Deng*, Zhi-Jun Sun*, “Two-Photon Absorption Induced Cancer Immunotherapy Using Covalent Organic Frameworks” Adv. Funct. Mater. 2021, 31, 2103056.
21. Kai Feng†, Liang Zhang†, Jiang Gong*, Jinping Qu, Ran Niu*, “Visible light triggered exfoliation of COF micro/nanomotors for efficient photocatalysis” Green Energy & Environment 2023, 8, 567-578.