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影响因子：1.5

DOI码：10.1063/1.4994736

发表刊物：Review of Scientific Instruments

摘要：We developed a microcantilever array biosensor instrument based on optical readout from a microcantilever array in fluid environment. The microcantilever signals were read out sequentially by laser beams emitted from eight optical fibers. The optical fibers were coupled to lasers, while the other ends of the fibers were embedded in eight V-grooves with 250 mum pitch microfabricated from a Si wafer. Aspherical lens was used to keep the distance between lasers. A programmable logic controller was used to make the system work stably. To make sure that the output of lasers was stable, a temperature controller was set up for each laser. When the deflection signal was collected, lasers used here were set to be on for at least 400 ms in each scanning cycle to get high signal-to-noise ratio deflection curves. A test was performed by changing the temperature of the liquid cell holding a microcantilever array to verify the consistent response of the instrument to the cantilever deflections. The stability and conformance of the instrument were demonstrated by quantitative detection of mercury ions in aqueous solution and comparison detection of clenbuterol by setting test and reference cantilevers. This microcantilever array detection instrument can be applied to highly sensitive detection of chemical and biological molecules in fluid environment.

合写作者：Li Chao,Wu Lin

第一作者：Zhang Guangping

论文类型：期刊论文

通讯作者：Wu Shangquan,Zhang Qingchuan

卷号：88

页面范围：075007

是否译文：否

发表时间：2017-07-01

收录刊物：SCI