A chemical timer approach to delayed chemiluminescence

Release time:2022-11-25  Hits:

• Impact Factor:11.41
• DOI number:10.1073/pnas.2207693119
• Journal:Proc. Natl. Acad. Sci. U.S.A.
• Abstract:Although the onset time of chemical reactions can be manipulated by mechanical, electrical, and optical methods, its chemical control remains highly challenging. Herein, we report a chemical timer approach for manipulating the emission onset time of chemiluminescence (CL) reactions. A mixture of Mn2+, NaHCO3, and a luminol analog with H2O2 produced reactive oxygen species (ROS) radicals and other superoxo species (superoxide containing complex) with high efficiency, accompanied by strong and immediate CL emission. Surprisingly, the addition of thiourea postponed CL emission in a concentration-dependent manner. The delay was attributed to a slow-generation-scavenging mechanism, which was found to be generally applicable not only to various types of CL reagents and ROS radical scavengers but also to popular chromogenic reactions. The precise regulation of CL kinetics was further utilized in dynamic chemical coding with improved coding density and security. This approach provides a powerful platform for engineering chemical reaction kinetics using chemical timers, which is of application potential in bioassays, biosensors, CL microscopic imaging, microchips, array chips, and informatics.
• Co-author:Wei Nie,Lu Yu,shujiangnan,Yaohua Li,Changlin Tian
• First Author:zhengtianhua
• Indexed by:Journal paper
• Correspondence Author:Hua Cui,Wei Wang
• Discipline:Natural Science
• Document Type:J
• Volume:119
• Issue:43
• Page Number:e2207693119
• Translation or Not:no
• Date of Publication:2022-10-17
• Included Journals:SCI
• Links to published journals:https://www.pnas.org/doi/10.1073/pnas.2207693119#bibliography