Cui Hua
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- Professor
- Supervisor of Doctorate Candidates
- Supervisor of Master's Candidates
- Name (English):Hua Cui
- Name (Pinyin):Cui Hua
- E-Mail:
- Business Address:环境资源楼-339
- Contact Information:0551－3600730
- Degree:Dr
- Professional Title:Professor
- Teacher College:Chemistry and Materials Science
Contact Information
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- Paper Publications
One-Pot Synthesis of N-(4-Aminobutyl)-N-ethylisoluminol Doping Cuprous Oxide Nanocubes for Label-Free Chemiluminescence Immunoassay of Cardiac Troponin I
Release time:2025-11-19 Hits:
- DOI number:10.1021/acs.analchem.5c00462
- Journal:Analytical Chemistry
- Abstract:In this study, a novel chemiluminescence (CL)-functionalized nanomaterial, designated as ABEI@Cu2O nanocubes, was synthesized by doping the CL reagent N-(4-aminobutyl)-N-ethylisoluminol (ABEI) into Cu2O nanocubes via a simple one-pot method. The Cu2O nanocubes not only functioned as an effective nanocarrier but also exhibited peroxidase-like activity, promoting the decomposition of H2O2 to enhance CL emission. The incorporation of ABEI into the Cu2O nanocubes resulted in the concentration of the CL reagent within the cubic structures, reducing the spatial distance between the catalyst and ABEI and, thereby, enhancing the CL signal. The robust and stable CL emission of ABEI@Cu2O nanocubes facilitated the development of a label-free CL immunoassay for the detection of cardiac troponin I (cTnI), a biomarker indicative of an acute myocardial infarction. This immunoassay demonstrated a wide linear detection range from 1.0 × 10–13 to 1.0 × 10–8 g/mL and a low detection limit of 3.27 × 10–14 g/mL, surpassing all existing CL immunoassays for cTnI detection. Moreover, the proposed immunoassay demonstrated excellent sensitivity and precision in the quantitative detection of cTnI in serum samples from both healthy individuals and patients. The exceptional sensitivity and flexibility of this immunoassay, supported by the unique properties of the ABEI@Cu2O nanocubes, highlight its significant potential for the detection of various biomarkers.
- First Author:张文灿
- Co-author:王慢莉,郑可颖
- Indexed by:Journal paper
- Correspondence Author:shujiangnan,Hua Cui
- Discipline:Natural Science
- Document Type:J
- Volume:97
- Issue:23
- Page Number:12116–12124
- Translation or Not:no
- Date of Publication:2025-06-04
- Included Journals:SCI
- Links to published journals:https://pubs.acs.org/doi/10.1021/acs.analchem.5c00462?ref=PDF
