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    崔华

    • 教授 博士生导师 硕士生导师
    • 教师英文名称:Hua Cui
    • 电子邮箱:
    • 办公地点:环境资源楼-339
    • 联系方式:0551-3600730
    • 学位:博士
    • 2006当选:国家杰出青年科学基金获得者

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    Dynamically Tunable Chemiluminescence of Luminol-Functionalized Silver Nanoparticles and Its Application to Protein Sensing Arrays

    点击次数:

    影响因子:6.785

    DOI码:10.1021/ac503123q

    发表刊物:Anal. Chem.

    摘要:It is still a great challenge to develop an array-based sensing system that can obtain only multiparameters, according to a single experiment and device. The role of conventional chemiluminescence (CL) in biosensing has been limited to a signal transducer in which a single signal (CL intensity) can be obtained for quantifying the concentrations of analytes. In this work, we have developed an dynamically tunable CL system, based on the reaction of luminol-functionalized silver nanoparticles (luminol–AgNPs) with H2O2, which could be tunable via adjusting various conditions such as the concentration of H2O2, pH value, and addition of protein. A single experiment operation could obtain multiparameters including CL intensity, the time to appear CL emission and the time to reach CL peak value. The tunable, low-background, and highly reproducible CL system based on luminol–AgNPs is applied, for the first time, as a sensing platform with trichannel properties for protein sensing arrays by principal component analysis. Identification of 35 unknowns demonstrated a success rate of >96%. The developed sensing arrays based on the luminol–AgNPs provide a new way to use nanoparticles-based CL for the fabrication of sensing arrays and hold great promise for biomedical application in the future.

    合写作者:何潇,刘晓英,高凌峰

    第一作者:何毅

    论文类型:期刊论文

    通讯作者:崔华

    论文编号:000346683900037

    学科门类:理学

    文献类型:J

    卷号:86

    期号:24

    页面范围:12166-12171

    ISSN号:0003-2700

    是否译文:

    发表时间:2014-12-16

    收录刊物:SCI

    发布期刊链接:https://pubs.acs.org/doi/10.1021/ac503123q