1) 非编码RNA的结构功能：主要使用溶液核磁共振方法（NMR）研究重要的非编码RNA的结构并了解其结构功能关系。在体外对RNA进行大规模转录的过程中，使用不同的标记策略（15N,13C,2H）对目标RNA进行稳定同位素标记，进一步使用多维核磁共振实验获取RNA序列和距离信息用于其结构构建。

• (I) Increasing evidences exhibited that non-coding RNA (ncRNA) or small RNA (sRNA) plays essential roles in many cellular processes including RNA splicing, gene regulation, and cancer development. However, the precise function of majority of ncRNA remains unclear. The structure-based investigation of RNAs and RNA complexes with proteins will definitely lead to a better understanding of mechanisms ncRNAs used for their variable functions.