Lv Xinyou
|
- Special Researcher
- Supervisor of Doctorate Candidates
- Supervisor of Master's Candidates
- Name (Pinyin):Lv Xinyou
- E-Mail:
- Administrative Position:特任研究员
- Education Level:Postgraduate (Postdoctoral)
- Business Address:南区人文与社会科学学院203
- Degree:Dr
- Professional Title:Special Researcher
- Alma Mater:浙江大学
- Teacher College:Humanities and Social Science
Contact Information
- PostalAddress：
- Email：
- Paper Publications
Retrieval-Extinction of drug memory requires AMPA receptor trafficking
Release time:2023-09-02 Hits:
- Impact Factor:14.957
- DOI number:10.1126/sciadv.add6642
- Journal:Science Advances
- Abstract:Disruption of drug-associated memory reduces relapse. Transient memory retrieval facilitates the upcoming extinction of addiction memory, while the neural basis for this beneficial outcome remains unelucidated. Here, we report that AMPA receptor trafficking acts as the central component for retrieval-extinction-based drug memory intervention. Drug memory retrieval transiently reduces AMPA receptor-mediated synaptic transmission in prefrontal cortical neurons (lasting for 2 to 4 hours) through rapid removal of calcium-permeable AMPA receptors from the synapse, which returned to basal state level after 6 hours. The receptor trafficking is orchestrated by dopamine D1 but not D2 receptor signaling. Blocking AMPA receptor trafficking abolishes retrieval-extinction-mediated addiction memory degradation. These results reveal the molecular mechanism underlying the efficacy of transient memory retrieval on helping to erase addiction memory and support targeting the prefrontal cortex to reduce relapse (e.g., with noninvasive brain stimulation).
- Indexed by:Article
- Volume:8
- Issue:51
- Translation or Not:no
- Date of Publication:2022-12-23
- Included Journals:SCI