English

陶余勇

电子邮箱：

学位：博士

基本信息
科学研究

研究方向

[1] 膜蛋白结构与功能研究。利用结构生物学研究方法，阐述高等生物跨膜蛋白介导物质转运和信号转导的分子机制

[2] 抗体设计与蛋白质工程改造。设计抗体、蛋白质文库并筛选具有所需活性的蛋白变体，用于基础研究和药物开发。

[3] 合成生物学。设计真核细胞正交信号通路，用于智能细胞设计和改造，达到针对特定疾病的精准治疗。

论文成果

[1] 1. Tao Y, Mis M, Blazer L, Ustav M Jnr, Steinhart Z, Chidiac R, Kubarakos E, O'Brien S, Wang X, Jarvik N, Patel N, Adams J, Moffat J, Angers S, Sidhu SS. (2019) Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice. Elife 8: e46134.2021,

[2] 3. Xu Y*, Tao Y*, Cheung L*, Fan C, Chen L, Xu S, Perry K, Frommer W, Feng L. (2014) Structures of bacterial homologues of SWEET transporters in two distinct conformations. Nature 515: 448-452 (* equal contributions).2021,

[3] 6. Guo Q, Tao Y, Liu H, Teng M, Li X. (2013) Structural insights into the role of the Chl4-Iml3 complex in kinetochore assembly. Acta Crystallographica Section D 69: 2412-2419.2021,

[4] 4. Tao Y, Jin C, Li X, Qi S, Chu L, Niu L, Yao X, Teng M. (2012) The structure of the FANCM-MHF complex reveals physical features for functional assembly. Nature Communications 3:782.2021,

[5] 5. Tao Y*, Li X*, Liu Y, Ruan J, Qi S, Niu L, Teng M. (2012) Structural analysis of Shu proteins reveals a DNA binding role essential for resisting damage. Journal of Biological Chemistry 287: 20231-9.2021,

[6] 2. Tao Y*, Cheung L*, Li S, Eom J, Chen L, Xu Y, Perry K, Frommer W, Feng L. (2015) Structure of a eukaryotic SWEET transporter in a homo-trimeric complex. Nature 527: 259-63.2021,

[7] 7. Qiu X, Tao Y, Zhu Y, Yuan Y, Zhang Y, Liu H, Gao Y, Teng M, Niu L. (2012) Structural insights into decreased enzymatic activity induced by an insert sequence in mannonate dehydratase from Gram negative bacterium. Journal of Structural Biology 180: 327-34.2021,

科研项目

[1] 中国科大-长春卓谊联合实验室2020年课题4（亚型选择性和识别表位特异性的FZD抗体设计和制备）,进行,

[2] 2019-nCoV冠状病毒突触蛋白的多表位特异性阻断分子研发,进行,

[3] 抗瘤菌基因线路的设计与合成,进行,

[4] Wnt信号通路Frizzled蛋白机制研究和特异性调控分子开发,进行,

[5] 真核细胞跨膜正交受体的人工设计及其应用,进行,

[6] 丝氨酸转运载体的结构特征和功能机制,进行,