Associate professor
Supervisor of Master's Candidates
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DOI number:10.1103/PhysRevLett.118.208102
Journal:Physical Review Letters
Abstract:Cell adhesion is an essential biological process. However, previous theoretical and experimental studies ignore a key variable, the changes of cellular volume and pressure, during the dynamic adhesion process. Here, we treat cells as open systems and propose a theoretical framework to investigate how the exchange of water and ions with the environment affects the shape and dynamics of cells adhered between two adhesive surfaces. We show that adherent cells can be either stable (convex or concave) or unstable (spontaneous rupture or collapse) depending on the adhesion energy density, the cell size, the separation of two adhesive surfaces, and the stiffness of the flexible surface. Strikingly, we find that the unstable states vanish when cellular volume and pressure are constant. We further show that the detachments of convex and concave cells are very different. The mechanical response of adherent cells is mainly determined by the competition between the loading rate and the regulation of the cellular volume and pressure. Finally, we show that as an open system the detachment of adherent cells is also significantly influenced by the loading history. Thus, our findings reveal a major difference between living cells and nonliving
First Author:Yuehua Yang
Indexed by:Journal paper
Correspondence Author:Hongyuan Jiang
Volume:118
Issue:20
Page Number:208102
ISSN No.:0031-9007, 1079-7114
Translation or Not:no
Date of Publication:2017-05-19
Included Journals:SCI
Links to published journals:http://link.aps.org/doi/10.1103/PhysRevLett.118.208102
