戴依聪

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主要科研项目
1. 国家自然科学基金面上项目,单分子G-四链体的电学特性及分子相互作用微观机制研究,2025年1月-2028年12月,参加,在研;
2. 国家博士后创新人才支持计划,增强子RNA文库高通量筛选策略用于肿瘤特异性CRISPR基因治疗,2023年7月-2025年7月,主持,结题;
3. 国家博士后科学基金面上项目,G-四链体解旋剂逆转三阴性乳腺癌化疗耐药的分子机制与基于类器官的临床前研究,2023年12月-2025年7月,主持,结题。
主要学术论文
1. Yicong Dai#; Xucong Teng#; Jinghong Li*; Single-Cell Visualization of Monogenic RNA G quadruplex and Occupied G-quadruplex Ratio through a Module-Assembled Multifunctional Probes Assay (MAMPA), Angewandte Chemie International Edition, 2021, 61(7): e202111132.
2. Qiushuang Zhang#; Yicong Dai#; Xucong Teng*; Jinghong Li*; Visualization and Quantification of Single-Base m6A Methylation, Angewandte Chemie International Edition, 2025, 64(6): e20240977.
3. Xucong Teng#; Difei Hu#; Yicong Dai#; Haitao Jing; Wenxuan Hu; Qiushuang Zhang; Na Zhang; Jinghong Li*; Discovery of A G-Quadruplex Unwinder That Unleashes the Translation of G-Quadruplex-Containing mRNA without Inducing DNA Damage, Angewandte Chemie International Edition, 2024, 63(38): e202407353.
4. Yicong Dai#; Xucong Teng#; Qiushuang Zhang; Hongwei Hou*; Jinghong Li*; Advances and Challenges in Identifying and Characterizing G-quadruplex–protein Interactions, Trends in Biochemical Sciences, 2023, 48(10): 894-909.
5. Yicong Dai#; Xucong Teng#; Difei Hu; Qiushuang Zhang; Jinghong Li*; Evolution of Monkeypox C9L RNA G-Quadruplex Elevates the Translation of Its Only Kelch-Like Protein by Accelerating G Quadruplex Unfolding Kinetics, CCS Chemistry, 2024, 6(4), 953-963.
6. Yicong Dai, Xucong Teng, Hongwei Hong*, Jinghong Li*, Visualization of Endogenous RNA G-quadruplex in Individual Genes in Single Cells, Chapter in “Methods in Molecular Biology”, Vol. 2822, Springer, 2024, ISSN 1064-3745.
7. Xucong Teng#; Yicong Dai#; Ke Li; Yuncong Wu; Hongwei Hou*; Jinghong Li*; LiveG4ID-Seq for Profiling the Dynamic Landscape of Chromatin G-Quadruplexes During Cell Cycle in Living Cells, Small Methods, 2023, 7(4): 2201487.
8. Xucong Teng#; Yicong Dai#; Jinghong Li*; Module Assembly Strategy for Single‐Cell Nucleic Acid Imaging at the Sub‐Molecule Level, Chemistry – A European Journal, 2022, 28(28): e202104628.
专利发明
1. 李景虹;侯宏卫;滕续聪;戴依聪;胡迪斐;一种促进小胶质细胞向M2表型转化的药物筛选系统及其构建方法和应用,2024-11-08,中国,CN202411014513.8(专利,发明公开)
2. 李景虹;滕续聪;赵轩;戴依聪;章秋爽;基于mRNA与点击化学分子的肿瘤特异性蛋白靶向降解剂及应用,2024-06-06,中国,CN202410727029.3(专利,发明公开)
3. 李景虹;滕续聪;胡迪斐;戴依聪;一种核酸G-四链体解旋剂及应用,2024-06-19,中国,CN202410789676.7(专利,发明授权)
4. 李景虹;滕续聪;戴依聪;一种小分子-DNA相互作用图谱测序方法以及试剂盒,2023-10-20,中国,CN202310855906.0(专利,发明授权)
5. 李景虹;滕续聪;戴依聪;一种高效染色质DNA结合图谱测序方法,2023-01-10,中国,ZL202310031360.7(专利,发明公开)