孙德猛 博士生导师  硕士生导师

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学位:博士

科学研究

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代表性论文:

1.       Cao X, Liu T, Wang T, Wang X, Xu Z, Zhou L, Tian C*, Sun D*. De Novo Screening and Mirror Image Isomerization of Linear Peptides Targeting α7 Nicotinic Acetylcholine Receptor. ACS Chem Biol. 2024, 19(3):592-598.

2.       Wang L, Li H, Wang X, Yang X, Tian C, Sun D*, Liu L, Li J*. Modification of Low-Energy Surfaces Using Bicyclic Peptides Discovered by Phage Display. J Am Chem Soc. 2023, 145(32):17613-17620.

3.       Wang T, Cao X, Zheng Y, Chen C, Zhou L, Sun D*, Fang G*, Tian C*. Total stepwise solid-phase synthesis of peptide-oligonucleotide conjugates using side-chain Boc/tBu protecting groups. Chem Commun (Camb). 2023, 59(39):5839-5842.

4.        Zuo C, Ding R, Wu X, Wang Y, Chu GC, Liang LJ, Ai H, Tong ZB, Mao J, Zheng Q, Wang T, Li Z, Liu L*, Sun D*. Thioester-Assisted Sortase-A-Mediated Ligation. Angew Chem Int Ed. 2022, 61(28):e202201887.

5.        Ling S, Shi P, Liu S, Meng X, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D*, Liu L* and Tian C*. Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca2+ ions and L-tryptophan. Cell Research 2021, 31, 383-394.

6.        Zhao Y, Liu S, Zhou Y, Zhang M, Chen H, Eric Xu H, Sun D*, Liu L*, and Tian C*. Structural basis of human alpha7 nicotinic acetylcholine receptor activation. Cell Research 2021 31, 713-716.

7.        Li Y#, Heng J#, Sun D*, Zhang B, Zhang X, Zheng Y, Shi W, Wang T, Li J, Zheng J*, Kibilka B and Liu L.* Chemical Synthesis of a Full-Length G-Protein-Coupled Receptor β2-Adrenergic Receptor with Defined Modification Patterns at the C-terminus. J Am Chem Soc 2021 143(42):17566-17576

8.        Li S#, Yang F#, Sun D#*, Zhang Y#, Zhang M, Liu S, Zhou P, Shi C, Zhang L*, and Tian C.* Cryo-EM structure of the hyperpolarization-activated inwardly rectifying potassium channel KAT1 from Arabidopsis. Cell Research 2020, 30: 1049-1052.

9.        Sun D#, Liu S#, Li S#, Zhang M#, Yang F, Wen M, Shi P, Wang T, Pan M, et al. Structural Insights into Human Acid-sensing Ion Channel 1a Inhibition by Snake Toxin Mambalgin1. Elife 2020, 9, e57096

10.     Sun D#, Yu Y#, Xue X#, Pan M#, Wen M, Li S, Qu Q, Li X., Zhang L, Li X, et al. Cryo-EM structure of the ASIC1a-mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect. Cell Discovery 2018, 4, 27.

11.     Guo Y#, Sun D#, Wang F#, He Y, Liu L, and Tian C. Diaminodiacid Bridges to Improve Folding and Tune the Bioactivity of Disulfide-Rich Peptides. Angew Chem Int Ed 2015 54, 14276-14281.