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Prof. Zheng Su is a research scientist (Assistant to the Chief of Orthopaedics - Associate Researcher - Subject Group Leader) with expertise in Bone infection and Immunity. He received his Ph.D. from the University of Science and Technology of China (USTC) in P.R. China in 2019. 1 year exchange visit to Queen's University Belfast, UK during PhD period. Prof. Su completed his postdoctoral training and was subsequently promoted to Assistant Professor at The First Affiliated Hospital of USTC in Hefei in 2022. His experience includes over 12 years of research focused primarily on 1) biomimetic agents regulating the body's immunity for the treatment of bone infections; 2) exploration of bacterial biofilm structures; and 3) development of bacterial detection test strips. In particular, his laboratory is interested in advancing research aims to elucidate these complex interactions to refine therapeutic strategies for managing infections and immune-mediated disorders. Promoting the development of public health and safety construction. Such as characterizing the structure of bacterial biofilms, understanding pathogen-induced immune mechanisms, optimizing immunomodulatory adjuvants, tackling chronic infections, advancing personalized medicine, strengthening public health strategies, and developing antimicrobial test strips etc. Published 14 SCI papers in Science Advances, Drug Resistance Updates, Nature Communications and other international journals as the first author, and 7 SCI papers in Nature Communications, Cell Reports Physical Science, ACS Nano, Biomaterials, Advanced Functional Materials (2), Bioactive Materials (2), Nano Today and other international journals as the corresponding author. He was voted in as the national commissioner of Geriatric Bone and Joint Disease Branch, Chinese Association of Geriatric Research (CAGR). He was the editorial board member of Scientific Reports. He was inviated as the Guest Editoer of Frontiers in Immunology. He was elected as the young editorial board member of Journal of Orthopaedic Translationd (Q1), Infectious Medicine, Burns & Trauma (Q1), Biomaterials Translational, and reviewed papers in International Journal of Biological Macromolecules, ACS Nano, ACS Applied & Interface Materials, Advanced Science, Composite Part B, Carbohydrate Polymers, Medical Gas Research and other SCI journals. Chairing the youth project of National Natural Science Foundation of China (NSFC), the top project of China Postdoctoral Foundation (CPDF), and the cultivation project of New Medicine of China University of Science and Technology (CUSTOMS); participating in the key R&D projects of the Ministry of Science and Technology (MOST), and the top project of the NSFC. He was awarded the first batch of Anhui Provincial Public Healthcare Institutions Introducing High-Level Talents Award, Hefei High-Level Talents Award, the nomination of Top Ten Scientific and Technological Advances of the Year by the Department of Biomedical Science and Medicine of the University of Science and Technology of China (USTC), and the "Mo Zi Outstanding Young Persons' Special Allowance" of the University of Science and Technology of China.
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Email: suz924@ustc.edu.cn
Published articles:
【#】. Su Zheng#; Kong Lingtong#; Dai Yong#; Tang Jin*; Mei Jiawei; Qian Zhengzheng; Ma Yuanyuan; Li Qianming; Ju Shenghong; Wang Jiaxing*; Fan Wenpei*; Zhu Chen*, Bioresponsive nano-antibacterials for H2S-sensitized hyperthermia and immunomodulation against refractory implant-related infections. Science Advances 2022, 8 (14), eabn1701.
【#】. Su Zheng#; Kong Lingtong#; Mei Jiawei; Li Qianming; Qian Zhengzheng; Ma Yuanyuan; Chen Yue; Ju Shenghong; Wang Jiaxing*; Jia Weitao*; Zhu Chen*; Fan Wenpei*, Enzymatic bionanocatalysts for combating peri-implant biofilm infections by specific heat-amplified chemodynamic therapy and innate immunomodulation. Drug Resistance Updates 2023, 67, 100917.
【#】. Su Zheng#*; Xu Dongdong#; Hu Xianli#; Zhu Wanbo*; Kong Lingtong; Qian Zhengzheng; Mei Jiawei; Ma Ruixiang; Shang Xifu; Fan Wenpei*; Zhu Chen*, Biodegradable oxygen-evolving metalloantibiotics for spatiotemporal sono-metalloimmunotherapy against orthopaedic biofilm infections. Nature Communications 2024, 15 (1), 8058.
【#】. Hu Xianli#; Ma Ruixiang#; Zhang Peng#; Dong Jiale; Sun Jiaxuan; Wang Wenzhi; Liu Quan; Kong Lingtong; Zhang Xudong; Wang Zhengxi; Mei Jiawei; Shang Xifu; Zhu Wanbo*; Su Zheng*; Zhu Chen*, Biomimetic Metal–Organic Framework Combats Biofilm-Associated Infections via Hyperthermia-Enhanced Bacterial Metabolic Interference and Autophagy-Promoted Adaptive Immunity. Advanced Functional Materials 2024, 34, 2310509.
【#】. Zhengxi Wang#; Xudong Zhang#; Quan Liu#; Xianli Hu; Jiawei Mei; Jun Zhou; Xianzuo Zhang; Dongdong Xu*; Wanbo Zhu*; Zheng Su*; Chen Zhu*, Balancing bioresponsive biofilm eradication and guided tissue repair via pro-efferocytosis and bi-directional pyroptosis regulation during implant surgery. ACS Nano 2024, 18(20), 13196-13213
【#】. Yang Ning#; Wu Ting#; Li Meng#, Hu Xianli; Zhang Xianzuo; Ma Ruixiang; Li Qianming; Jiang Wei; Su Zheng*; Yang Rong*; Zhu Chen*, Silver-Quercetin-loaded honeycomb-like Ti-based interface combats infection-triggered excessive inflammation via specific bactericidal and macrophage reprogramming. Bioactive Materials 2024, In press.
【#】. Liu Quan#; Mei Jiawei#; Wang Zhengxi#; Zhang Xudong; Hu Xianli; Xu Dongdong; Zhou Jun; Li Qianming; Ma Ruixiang; Zhang Xianzuo; Su Zheng*; Zhu Wanbo*; Zhu Chen*, Nano-Fat Actuated Lipometabolic Reprogramming of Macrophages for Intracellular Infections in Biofilm Microenvironment. Advanced Functional Materials 2024, 2405852.
【#】. Xu Dongdong#; Hu Jun#; Mei Jiawei#; Zhou Jun; Wang Zhengxi; Zhang Xudong; Liu Quan; Su Zheng*; Zhu Wanbo*; Liu Hongjian*; Zhu Chen*, Nanoadjuvant-triggered STING activation evokes systemic immunotherapy for repetitive implant-related infections. Bioactive Materials 2024, 35, 82-98.
【#】. Dong Jiale#; Zhou Wei#; Hu Xianli#; Bai Jiaxiang*; Zhang Siming; Zhang Xianzuo; Yu Lei; Yang Peng; Kong Lingtong; Liu Mingkai; Shang Xifu; Su Zheng*; Geng Dechun*; Zhu Chen*, Honeycomb-inspired ZIF-sealed interface enhances osseointegration via anti-infection and osteoimmunomodulation. Biomaterials 2024, 307, 122515.
【#】. Li Qianming#; Liu Quan#; Wang Zhengxi; Zhang Xianzuo; Ma Ruixiang; Hu Xianli; Mei Jiawei*; Su Zheng*; Zhu Wanbo*; Zhu Chen*, Biofilm Homeostasis Interference Therapy via 1O2-Sensitized Hyperthermia and Immune Microenvironment Re-Rousing for Biofilm-Associated Infections Elimination. Small 2023, 19, 2300592.
【#】. Zhang Xudong#; Wang Zhengxi#; Liu Quan#; Hu Xianli; Mei Jiawei; Xu Dongdong; Zhou Jun; Zhang Xianzuo; Li Qianming; Chen Hua; Su Zheng*; Zhu Wanbo*; Zhu Chen*, Targeted modulation and enhancement of macrophages via sonodynamic therapy-driven cupferroptosis-like stress for implant-associated biofilm infections. Nano Today 2024, 54, 102092.
【#】. Yang Jiazhao; Zhang Xudong; Lu Baoliang; Mei Jiawei; Xu Lei; Zhang Xianzuo; Su Zheng; Xu Wei; Fang Shiyuan; Zhu Chen; Xu Dongdong; Zhu Wanbo, Inflammation-Responsive Hydrogel Spray for Synergistic Prevention of Traumatic Heterotopic Ossification via Dual-Homeostatic Modulation Strategy. Advanced Science 2023, n/a (n/a), 2302905.
【#】. Mei Jiawei; Xu Dongdong; Wang Lingtian; Kong Lingtong; Liu Quan; Li Qianming; Zhang Xianzuo; Su Zheng; Hu Xianli; Zhu Wanbo; Ye Ming; Wang Jiaxing; Zhu Chen, Biofilm Microenvironment-Responsive Self-Assembly Nanoreactors for All-stage Biofilm Associated Infection through Bacterial Cuproptosis-like Death and Macrophage Re-rousing. Advanced Materials 2023, 35, 2303432.
【#】. Zhu Wanbo; Mei Jiawei; Zhang Xianzuo; Zhou Jun; Xu Dongdong; Su Zheng; Fang Shiyuan; Wang Jiaxing; Zhang Xianlong; Zhu Chen, Photothermal Nanozyme-based Microneedle Patch against Refractory Bacterial Biofilm Infection via Iron-actuated Janus Ion Therapy. Advanced Materials 2022, 34, 2207961.
【#】. Ma Yuanyuan; Su Zheng; Zhou Liming; He Liangcan; Hou Zhenyu; Zou Jianhua; Cai Yu; Chang Di; Xie Jinbing; Zhu Chen; Fan Wenpei; Chen Xiaoyuan; Ju Shenghong, Biodegradable Metal-Organic Framework-Gated Organosilica for Tumor Microenvironment-Unlocked Glutathione Depletion-Enhanced Synergistic Therapy. Advanced Materials 2022, 32, 2107560.
【#】. Ma Ruixiang; Hu Xianli; Zhang Xianzuo; Wang Wenzhi; Sun Jiaxuan; Su Zheng*; Zhu Chen*, Strategies to prevent, curb and eliminate biofilm formation based on the characteristics of various periods in one biofilm life cycle. Frontiers in Cellular and Infection Microbiology 2022, 12, 1003033.
【#】. Ye Xianzhu; Wang Hua; Zheng Kang; Wu Zhaofeng; Zhou Haifeng; Tian Konghu; Su Zheng; Tian Xingyou, The interface designing and reinforced features of wood fiber/polypropylene composites: Wood fiber adopting nano-zinc-oxide-coating via ion assembly. Composites Science and Technology 2016, 124, 1-9.
【#】. Su Zheng; Sun Daye; Zhang Li; He Miaomiao; Jiang Yulin; Millar Bronagh; Douglas Paula; Mariotti Davide; Maguire Paul; Sun Dan*, Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions. Materials 2021, 14 (9), 2351.
【#】. Su Zheng; Wang Hua*; Tian Xingyou*, Time and space dependence of large-scale synthesis of colloidal particle with special morphology and tuneable polymer film architecture. International Journal of Adhesion and Adhesives 2019, 95, 102380.
【#】. Su Zheng; Wang Hua*; He Jing; Guo Yulan; Qu Qiqi; Tian Xingyou*, Fabrication of Thermal Conductivity Enhanced Polymer Composites by Constructing an Oriented Three-Dimensional Staggered Interconnected Network of Boron Nitride Platelets and Carbon Nanotubes. ACS Applied Materials & Interfaces 2018, 10 (42), 36342-36351.
【#】. Su Zheng; Wang Hua*; Tian Konghu; Huang Weiqi; Xiao Chao; Guo Yulan; He Jing; Tian Xingyou*, The combination of π-π interaction and covalent bonding can synergistically strengthen the flexible electrical insulating nanocomposites with well adhesive properties and thermal conductivity. Composites Science and Technology 2018, 155, 1-10.
【#】. Su Zheng; Wang Hua*; Tian Konghu; Huang Weiqi; Guo Yulan; He Jing; Tian Xingyou*, Multifunctional anisotropic flexible cycloaliphatic epoxy resin nanocomposites reinforced by aligned graphite flake with non-covalent biomimetic functionalization. Composites Part A: Applied Science and Manufacturing 2018, 109, 472-480.
【#】. Su Zheng; Wang Hua*; Ye Xianzhu; Tian Konghu; Huang Weiqi; He Jing; Guo Yulan; Tian Xingyou*, Anisotropic thermally conductive flexible polymer composites filled with hexagonal born nitride (h-BN) platelets and ammine carbon nanotubes (CNT-NH2): Effects of the filler distribution and orientation. Composites Part A: Applied Science and Manufacturing 2018, 109, 402-412.
【#】. Su Zheng; Wang Hua*; Ye Xianzhu; Tian Konghu; Huang Weiqi; He Jing; Guo Yulan; Tian Xingyou*, Synergistic enhancement of anisotropic thermal transport flexible polymer composites filled with multi-layer graphene (mG) and mussel-inspiring modified hexagonal boron nitride (h-BN). Composites Part A: Applied Science and Manufacturing 2018, 111, 12-22.
【#】. Su Zheng; Wang Hua*; Ye Xianzhu; Tian Konghu; Huang Weiqi; Xiao Chao; Tian Xingyou*, Enhanced thermal conductivity of functionalized-graphene/boron nitride flexible laminated composite adhesive via a facile latex approach. Composites Part A: Applied Science and Manufacturing 2017, 99, 166-175.
【#】. Su Zheng; Wang Hua*; Ye Xianzhu; Tian Konghu; Huang Weiqi; Guo Yulan; He Jing; Tian Xingyou*, Non-covalent poly (2-ethylhexyl acrylate) (P2EHA)/functionalized graphene/h-boron nitride flexible composites with enhanced adhesive and thermal conductivity by a facilitated latex approach. Composites Part A: Applied Science and Manufacturing 2017, 99, 176-185.
【#】. Su Zheng; Wang Hua*; Xu Fei; Tian Konghu; Wu Jingwei; Tian Xingyou*, Tunable composite architecture and homogeneous dispersion of charged SiO2 in polymer matrix assisted by poly(2-ethylhexyl acrylate) (P2EHA) latex prepared by self-assembly through electrostatic interactions. Rsc Advances 2016, 6 (7), 5621-5630.
【#】. Su Zheng; Wang Hua*; Tian Konghu; Xu Fei; Huang Weiqi; Tian Xingyou*, Simultaneous reduction and surface functionalization of graphene oxide with wrinkled structure by diethylenetriamine (DETA) and their reinforcing effects in the flexible poly(2-ethylhexyl acrylate) (P2EHA) films. Composites Part A: Applied Science and Manufacturing 2016, 84, 64-75.