植物是地球生命这一绚丽画卷的背景色。植物为其他生物——包括人类——提供了氧气、食物和能源。采用现代科学技术手段研究植物（包括粮食作物和经济作物）具有重大的理论意义和应用价值。十分有趣的是，植物营固着生活，面临环境中的危险信号时，不能像动物那样逃跑或斗争，因而在分子水平上进化出了复杂的机制。现在科学技术的发展让我们有机会揭开植物生命活动的神秘面纱，对背后的分子机理一窥究竟。

      从科学史上来看，在生物学研究领域，植物学研究也必不可少，并为现代生命科学的开端奠定了基础——19世纪，达尔文（——就是写出《物种起源》的那个达尔文，提出了生物进化学说）最早开始采用科学实验的方法研究植物的向光性、向重力性等问题；而同时期，孟德尔通过豌豆杂交实验发现了遗传学的基本法则，被称为“遗传学之父”。现代农业的绿色革命更是为解决地球人口增长面临的粮食短缺问题提供了重要帮助。

      我们课题组关注的生物学问题包括研究植物激素（集中于生长素和水杨酸等）协同调控生长发育的分子机理，以及与之相关的植物适应环境（光、重力等）的可塑性发育机制和植物内源天然化合物的细胞生物学功能。力图探明这些生物学过程中的生物化学事件（比如蛋白互作、蛋白翻译后修饰及蛋白稳定性等）和细胞生物学动态。主要研究手段包括：1）传统的正向/反向遗传学、生物化学和细胞生物学；2）前沿分子互作检测技术，如等温热滴定（ITC）等；3）以及采用先进显微成像技术和图像分析手段，研究细胞的精细结构和实时动态、并深入解析其分子机制。主要科研成果包括：1）磷脂通过蛋白激酶PDK1调控植物激素生长素极性运输的细胞与分子机理；2）抗逆激素水杨酸靶向蛋白磷酸酶PP2A调控PIN介导的生长素转运和根生长发育的分子机制；3）人工合成非甾醇类消炎药物（NSAIDs）结合分子伴侣蛋白TWD1参与微丝细胞骨架动态和囊泡运输、以及PIN极性定位的细胞与分子基础等。共发表SCI论文40余篇。其中，以第一作者或通讯作者（含共同）于Nature Plants、Current Biology、Molecular Plant、The Plant Cell和Cell Reports等学术期刊发表论文16篇。此外，以合作作者于Science、Nature、Advanced Science、PNAS、The EMBO Journal、Nature Communications和eLife等发表多篇研究论文。相关研究3篇文章受到 Faculty Opinions推荐，3篇为ESI高被引论文。入选国家海外人才计划青年项目，曾获得EMBO Long-Term Fellowship和Marie Curie COFUND等奖项。现任Faculty Opinions的Associate faculty member（2018.02-）、Molecular Plant的Feature editor（2020.06-）和Frontiers in Plant Science的Review editor（2021.04-）。

生长素与植物发育（Tan et al., Molecular Plant, 2021）

研究课题

1. 植物激素生长素极性运输的调控。

2. 生长素及其相关途径影响植物株型和根系形态。

3. 植物激素水杨酸与生长素互作调控植物生长发育。

4. 植物天然产物的细胞生物学活性。

发表论文

(^#, contributed equally to the article; *, corresponding author).

2024年

36. Wei Ying^#, Yaowei Wang^#, Hong Wei^#, Yongming Luo^#, Qian Ma, Heyuan Zhu, Hilde Janssens, Nemanja Vukašinović, Miroslav Kvasnica, Johan M. Winne, Yongxiang Gao, Shutang Tan, Jiří Friml, Xin Liu*, Eugenia Russinova* & Linfeng Sun*. Structure and function of the Arabidopsis ATP-binding cassette transporter ABCB19 in brassinosteroid export. Science. 2024, 383(6689): eadj4591. 

    DOI: 10.1126/science.adj4591  PMID: 38513023

2023年

35. Suruchi Roychoudhry, Katelyn Sageman-Furnas, Chris Wolverton, Peter Grones, Shutang Tan, Gergely Molnar, Heather L. Goodman, Nicola Capstaff, Jack Mullen, Roger Hangarter, Jiri Friml, and Stefan Kepinski*. Antigravitropic PIN polarization maintains non-vertical growth in lateral roots. Nature Plants,  2023, 9(9): 1500-1513.  

    DOI: 10.1038/s41477-023-01478-x  PMID: 37666965

34. Jing Xia^#, Mengjuan Kong^#, Zhisen Yang^#, Lianghanxiao Sun, Yakun Peng, Yanbo Mao, Hong Wei, Wei Ying, Yongxiang Gao, Jiri Friml, Jianping Weng*, Xin Liu*, Linfeng Sun*, & Shutang Tan*. Chemical inhibition of Arabidopsis PIN-FORMED auxin transporters by the anti-inflammatory drug naproxen. Plant Communications. 2023,  4(6): 100632. 

    DOI: 10.1016/j.xplc.2023.100632  PMID: 37254481

33.  Jing Zhang, Pingxia Zhao*, Siyan Chen, Liangqi Sun, Jieli Mao,Shutang Tan, Chengbin Xiang*. The ABI3-ERF1 module mediates ABA-auxin crosstalk to regulate lateral root emergence. Cell Reports. 2023, 42(7): 112809.

    DOI: 10.1016/j.celrep.2023.112809  PMID: 37450369

32. Pingxia Zhao^#*, Jing Zhang^#, Siyan Chen, Zisheng Zhang, Guangyu Wan, Jieli Mao, Zhen Wang, Shutang Tan, and Chengbin Xiang*. ERF1 inhibits lateral root emergence by promoting local auxin accumulation and repressing ARF7 expression. Cell Reports. 2023, 42(6): 112565. 

    DOI: 10.1016/j.celrep.2023.112565  PMID: 37224012

2022年

31. Mengjuan Kong, Xin Liu, Linfeng Sun*, and Shutang Tan*. Molecular mechanisms of N-1-naphthylphthalamic acid, a chemical tool in plant biology and agriculture. Molecular Horticulture. 2022, 2: 22. 

    DOI: https://doi.org/10.1186/s43897-022-00043-y

30. Nataliia Konstantinova, Lukas Hörmayer, Matouš Glanc, Rabab Keshkeih, Shutang Tan, Martin Di Donato, Katarzyna Retzer, Jeanette Moulinier-Anzola, Max Schwihla, Barbara Korbei, Markus Geisler, Jiří Friml, and Christian Luschnig*. WAVY GROWTH Arabidopsis E3 ubiquitin ligases affect apical PIN sorting decisions. Nature Communications. 2022, 13: 5147. 

DOI: 10.1038/s41467-022-32888-8     PMID: 36050482

29. Jiří Friml*, Michelle Gallei^#, Zuzana Gelová^#, Alexander Johnson^#, Ewa Mazur^#, Aline Monzer^#, Lesia Rodriguez^#, Mark Roosjen^#, Inge Verstraeten^#, Branka Zivanovic^#, Minxia Zou^#, Lukáš Fiedler, Caterina Giannini, Peter Grones, Monika Hrtyan, Walter A. Kaufmann, Madhumitha Narasimhan, Marek Randuch, Nikola Rýdza, Koji Takahashi, Shutang Tan, Toshinori Kinoshita, Dolf Weijers, Hana Rakusova. ABP1-TMK auxin perception for global phosphorylation and auxin canalization. Nature. 2022, 609(7927). 

DOI: 10.1038/s41586-022-05187-x  PMID: 36071161

28. Zhisen Yang^#, Jing Xia^#, Jingjing Hong^#, Chenxi Zhang, Hong Wei, Wei Ying, Chunqiao Sun, Lianghanxiao Sun, Yanbo Mao, Yongxiang Gao, Shutang Tan, Jiří Friml, Dianfan Li, Xin Liu*, and Linfeng Sun*. Structural insights into auxin recognition and efflux by Arabidopsis PIN1. Nature. 2022, 609(7927). 

DOI: 10.1038/s41586-022-05143-9  PMID: 35917925

27. Jakub Hajný, Shutang Tan, and Jiří Friml*. Auxin canalization: From speculative models towards molecular players. Current Opinion in Plant Biology. 2022, 65:102174. (Review; *, corresponding author).

    DOI: 10.1016/j.pbi.2022.102174  PMID: 35123880

2021年

26. Yanbo Mao*, and Shutang Tan*. Functions and Mechanisms of SAC Phosphoinositide Phosphatases in Plants. Frontiers in Plant Science. 2021,12: 803635. (Review; *, corresponding author).

    DOI: 10.3389/fpls.2021.803635  PMID: 34975993

25. Yakun Peng, and Shutang Tan*. TMK: A Crucial Piece of the Acid Growth Puzzle. Molecular Plant. 2021, 14(12): 1982–1984. (Spotlight; *, corresponding author).

    DOI: https://doi.org/10.1016/j.molp.2021.11.010 PMID: 34813950

24. Yanbo Mao*, and Shutang Tan*. Pollen hydration: A tale of two peptides. Molecular Plant. 2021, 14(7): 1049.

    DOI: https://doi.org/10.1016/j.molp.2021.05.025

23. Wei Kong^#, Shutang Tan^#, Qing Zhao, De-Li Lin, Zhi-Hong Xu, Jiří Friml, and Hong-Wei Xue*. mRNA surveillance complex PELOTA-HBS1 regulates Phosphoinositide-Dependent Protein Kinase1 and plant growth. Plant Physiology. 2021, 186.

DOI: https://doi.org/10.1093/plphys/kiab199 PMID: 33930167

22. Cheng-Wu Liu*, and Shutang Tan*. Nitrate signaling: a translator between nitrate perception and calcium signaling. Molecular Plant. 2021, 14(5): 718-719.

DOI: https://doi.org/10.1016/j.molp.2021.04.002

21. Matouš Glanc^#, Kasper Van Gelderen^#, Lukas Hörmayer, Shutang Tan, Satoshi Naramoto, Xixi Zhang, David Domjan, Ludmila Včelařová, Robert Hauschild, Alexander Johnson, Edward de Koning, Maritza van Dop, Eike Rademacher, Stef Janson, Xiaoyu Wei, Gergely Molnár, Matyáš Fendrych, Bert De Rybel, Remko Offringa,* and Jiří Friml*. AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells. Current Biology. 2021, 31(9): 1918-1930.

    DOI: https://doi.org/10.1016/j.cub.2021.02.028 PMID: 33705718

20. Madhumitha Narasimhan, Michelle Gallei, Shutang Tan, Alexander Johnson, Inge Verstraeten, Lanxin Li, Lesia Rodriguez, Huibin Han, Ellie Himschoot, Ren Wang, Steffen Vanneste, Judit Sánchez-Simarro, Fernando Aniento, Maciek Adamowski, and Jiří Friml*. Systematic analysis of specific and nonspecific auxin effects on endocytosis and trafficking. Plant Physiology. 2021, 186(2): 1122-1142.

DOI: https://doi.org/ 10.1093/plphys/kiab134. PMID: 33734402

19. Shutang Tan*. Action mode of NPA: direct inhibition on PIN auxin transporters. Molecular Plant. 2021, 14(2): 199.

DOI: https://doi.org/10.1016/j.molp.2021.01.010. 

18. Shutang Tan*. Repressors for auxin responsive transcriptional activators. Molecular Plant. 2021, 14(1): 8.

DOI: https://doi.org/10.1016/j.molp.2020.12.009.

17. Shutang Tan, Christian Luschnig, and Jiří Friml*. Pho-view of auxin: Reversible protein phosphorylation in auxin biosynthesis, transport and signalling. Molecular Plant. 2021. 14(1): 151-165.

DOI: https://doi.org/10.1016/j.molp.2020.11.004. PMID: 33186755

16. Krisztina Ötvös, Marco Marconi, Andrea Vega, Jose O’Brien, Alexander Johnson, Rashed Abualia, Livio Antonielli, Juan Carlos Montesinos López, Yuzhou Zhang, Shutang Tan, Candela Cuesta, Christina Artner,  Eleonore Bouguyon, Alain Gojon, Jirí Friml, Rodrigo A. Gutiérrez, Krzysztof Wabnik,* and Eva Benková*. Modulation of plant root growth by nitrogen source-defined regulation of polar auxin transport. The EMBO Journal. 2021, 40(3): e106862.

DOI: https://doi.org/10.15252/embj.2020106862. PMID: 33399250

15. Meiyu Ke^#, Zhiming Ma^#, Deyan Wang, Yanbiao Sun, Chenjin Wen, Dingquan Huang, Zichen Chen, Liang Yang, Shutang Tan, Ruixi Li, Jiří Friml, Yansong Miao,* and Xu Chen*. Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana. New Phytologist. 2021. 229(2):963-978.

DOI: https://doi.org/10.1111/nph.16915. PMID: 32901934

14. Hongjiang Li, Daniel von Wangenheim, Xixi Zhang, Shutang Tan, Nasser Darwish-Miranda, Satoshi Naramoto, Krzysztof Wabnik, Riet De Rycke, Walter A. Kaufmann, Daniel Gütl, Ricardo Tejos, Peter Grones, Meiyu Ke, Xu Chen, Jan Dettmer, and Jiří Friml*. Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana. New Phytologist. 2021. 229(1):351-369.  

DOI: https://doi.org/10.1111/nph.16887. PMID: 32810889

2020年

13. Shutang Tan, Xixi Zhang, Wei Kong, Xiao-Li Yang, Gergely Molnár, Zuzana Vondráková, Roberta Filepová, Jan Petrášek, Jiří Friml*, and Hong-Wei Xue*. The lipid code-dependent phosphoswitch PDK1-D6PK activates PIN-mediated auxin efflux in Arabidopsis. Nature Plants. 2020, 6(5): 556-569.

DOI: https://doi.org/10.1038/s41477-020-0648-9. PMID: 32393881

12. Shutang Tan, Melinda Abas, Inge Verstraeten, Matouš Glanc, Gergely Molnár, Jakub Hajný, Pavel Lasák, Ivan Petřík, Eugenia Russinova, Jan Petrášek, Ondřej Novák, Jiří Pospíšil, and Jiří Friml*. Salicylic acid targets Protein Phosphatase 2A to attenuate growth in plants. Current Biology. 2020, 30(3): 381-395.e8.

    DOI: https://doi.org/10.1016/j.cub.2019.11.058. PMID: 31956021.

11. Shutang Tan, Martin Di Donato, Matouš Glanc, Xixi Zhang, Petr Klima, Noel Ferro, Aurélien Bailly, Jan Petrášek, Markus Geisler, and Jiří Friml*. Non-steroidal anti-inflammatory drugs target TWISTED DWARF1-regulated actin dynamics and auxin transport-mediated development in plants. Cell Reports. 2020, 30(9): 108463.

DOI: https://doi.org/10.1016/j.celrep.2020.108463. PMID: 33264621

10. Jakub Hajný, Tomáš Prát, Nikola Rydza, Lesia Rodriguez, Shutang Tan, Inge Verstraeten, David Domjan, Ewa Mazur, Elwira Smakowska-Luzan, Wouter Smet, Eliana Mor, Jonah Nolf, BaoJun Yang, Wim Grunewald, Gergely Molnár, Youssef Belkhadir, Bert De Rybel and Jiří Friml*. Receptor kinase module targets PIN-dependent auxin transport during canalization. Science. 2020. 370(6516):550-557.

DOI: https://doi.org/10.1126/science.aba3178. PMID: 33122378

9. Xixi Zhang, Maciek Adamowski, Petra Marhava, Shutang Tan, Yuzhou Zhang, Lesia Rodriguez, Marta Zwiewka, Vendula Pukyšová, Adrià Sans Sánchez, Vivek Raxwal, Christian Hardtke, Tomasz Nodzyński, and Jiří Friml*. Arabidopsis flippases cooperate with ARF GTPase Exchange Factors to regulate the trafficking and polarity of PIN auxin transporters. The Plant Cell. 2020, 32(5): 1644-1664.

DOI: https://doi.org/10.1105/tpc.19.0086. PMID: 32193204

8. Madhumitha Narasimhan^#, Alexander Johnson^#, Roshan Prizak, Walter Anton Kaufmann, Shutang Tan, Barbara Casillas-Pérez, and Jiří Friml*. Evolutionarily unique mechanistic framework of clathrin-mediated endocytosis in plants. eLife. 2020, 9: e52067.

    DOI: https://doi.org/10.7554/eLife.52067. PMID: 31971511.

7. Yang Li^#, Yaping Wang^#, Shutang Tan, Matouš Glanc, Zhi Yuan, David Domjan, Kai Wang, Zhen Li, Yan Guo, Zhizhong Gong, Jiří Friml and Jing Zhang*. Root growth adaptation is mediated by PYLs ABA receptor-PP2A protein phosphatase complex. Advanced Science. 2020, 7(3): 1901455.

DOI:10.1002/advs.201901455. PMID: 32042554.

2019年及以前

6. Dingquan Huang^#, Yanbiao Sun^#, Zhiming Ma^#, Meiyu Ke, Yong Cui, Zichen Chen, Chaofan Chen, Changyang Ji, Tuan Minh Tran, Liang Yang, Sin Man Lam, Yanhong Han, Guanghou Shui, Zhuang Wei, Shutang Tan, Kan Liao, Jiří Friml, Yansong Miao, Liwen Jiang, and Xu Chen*. Salicylic acid-mediated plasmodesmal closure via Remorin-dependent lipid organization. PNAS. 2019, 116 (42): 21274-21284.

DOI: https://doi.org/10.1073/pnas.1911892116. PMID: 31575745

5. Marta Zwiewka^#, Agnieszka Bielach^#, Prashanth Tamizhselvan, Sharmila Madhavan, Eman Elrefaay Ryad, Shutang Tan, Mónika Hrtyan, Petre Dobrev, Rodamira Vaňková, Jiří Friml, and Vanesa B. Tognetti*. Root adaptation to H2O2-induced oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking. Plant and Cell Physiology. 2019, 60(2): 255-273. (cover).

DOI: https://doi.org/10.1093/pcp/pcz001. PMID: 30668780.

4. Yong Tang^#, Chun-Yan Zhao^#, Shu-Tang Tan, and Hong-Wei Xue*. Arabidopsis type II Phosphatidylinositol 4-Kinase PI4Kγ5 regulates auxin biosynthesis and leaf margin development through interacting with membrane-bound transcription factor ANAC078. PLoS Genetics. 2016, 12(8): e1006252.

DOI: https://doi.org/10.1371/journal.pgen.1006252. PMID: 27529511.

3. Shu-Tang Tan, and Hong-Wei Xue*. Casein kinase 1 regulates ethylene synthesis by phosphorylating and promoting the turnover of ACS5. Cell Reports. 2014, 9(5): 1692-1702.

DOI:10.1016/j.celrep.2014.10.047. PMID: 25464840.

2. Shu-Tang Tan, Cheng Dai, Hong-Tao Liu, and Hong-Wei Xue*. Arabidopsis casein kinase1 proteins CK1.3 and CK1.4 phosphorylate cryptochrome2 to regulate blue light signaling. The Plant Cell. 2013, 25(7): 2618-2632.

   DOI: https://doi.org/10.1105/tpc.113.114322. PMID: 23897926.

1. Yong Tang, Shu-Tang Tan, and Hong-Wei Xue*. Arabidopsis inositol 1,3,4-trisphosphate 5/6 kinase 2 is required for seed coat development. Acta Biochimica et Biophysica Sinica. 2013, 45(7): 549-560.

   DOI: https://doi.org/10.1093/abbs/gmt039. PMID: 23595027.

 

联系方式

        安徽省合肥市蜀山区黄山路443号，230027，中国科学技术大学西区生命科学学院。

        E-mail: sttan[at]ustc.edu.cn

 

招生招聘

        实验室常年招聘有植物分子遗传学、植物细胞生物学、发育生物学或植物学相关背景的博士后或特任副研究员（需两年及以上博士后或类似科研经历，并有较为优秀的科研成果），同时欢迎生物学或农学背景的本科生来本实验室实习或攻读博士学位（仅招收硕博连读研究生）。

 

更多信息

        ORCID:https://orcid.org/0000-0002-0471-8285

        ResearchGate:https://www.researchgate.net/profile/Shutang_Tan

        Homepage: https://biomed.ustc.edu.cn/2020/1124/c31898a570387/page.htm