Scientific Research

Research Field

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Paper Publications

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• Zhang Zhiyong.Determining structural ensembles of flexible multi-domain proteins using small-angle X-ray scattering and molecular dynamics simulations.PROTEIN & CELL,2015,6(8):619-623.
• Zhang Zhiyong.SAXS-Oriented Ensemble Refinement of Flexible Biomolecules.BIOPHYSICAL JOURNAL,2017,112(7):1295-1301.
• Zhang Zhiyong.Unraveling low-resolution structural data of large biomolecules by constructing atomic models with experiment-targeted parallel cascade selection simulations.SCIENTIFIC REPORTS,2016,6
• Zhang Zhiyong.pH dependence of ligand-induced human epidermal growth factor receptor activation investigated by molecular dynamics simulations.JOURNAL OF MOLECULAR MODELING,2016,22(6):
• Zhang Zhiyong.CLUSTERING MULTI-DOMAIN PROTEIN STRUCTURES IN THE ESSENTIAL DYNAMICS SUBSPACE.JOURNAL OF THEORETICAL & COMPUTATIONAL CHEMISTRY,2013,12(8):
• Zhang Zhiyong,Zhang Zhiyong.Systematic Methods for Defining Coarse-Grained Maps in Large Biomolecules.ADVANCE IN STRUCTURAL BIOINFORMATICS,2014,82733-48.

Patents

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Published Books

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• [11] Debiao Zhao, Xuejuan Wang, Junhui Peng, Chongyuan Wang, Fudong Li, Qianqian Sun, Yibo Zhang, Jiahai Zhang, Gang Cai, Xiaobing Zuo, Jihui Wu, Yunyu Shi, Zhiyong Zhang*, Qingguo Gong*. Structural investigation of the interaction between the tandem SH3 domains of c-Cb1-associated protein and vinculin. Journal of Structural Biology 2014 (187): 194-205.2021-09-03
• [10] Junhui Peng, Zhiyong Zhang*. Simulating large-scale conformational changes of proteins by accelerating collective motions obtained from principal component analysis. Journal of Chemical Theory and Computation 2014 (10): 3449-3458.2021-09-03
• [09] Bin Wen#, Junhui Peng#, Xiaobing Zuo, Qingguo Gong, Zhiyong Zhang*. Characterization of protein flexibility using small-angle X-ray scattering and amplified collective motion simulations. Biophysical Journal 2014 (107): 956-964.2021-09-03
• [04] Junhui Peng, Zhiyong Zhang*. Unraveling low-resolution structural data of large biomolecules by constructing atomic models with experiment-targeted parallel cascade selection simulations. Scientific Reports2016 (6): 29360.2021-09-03
• [03] Peng Cheng#, Junhui Peng#, Zhiyong Zhang*. SAXS-oriented ensemble refinement of flexible biomolecules. Biophysical Journal 2017 (112): 1295-1301.2021-09-03
• [02] Bin Wen, Weiwei Wang, Jiahai Zhang, Qingguo Gong, Yunyu Shi, Jihui Wu*, Zhiyong Zhang*. Structural and dynamic properties of the C-terminal region of the Escherichia coli RNA chaperone Hfq: integrative experimental and computational studies. Physical Chemistry Chemical Physics 2017 (19): 21152-21164.2021-09-03

Research Projects

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• （3）国家自然科学基金面上项目，21573205，计算机模拟整合冷冻电镜结构研究生物大分子复合物的组装,
• （2）国家自然科学基金面上项目，31270760，多尺度模拟集成小角散射数据研究蛋白质构象变化的方法,
• （1）科技部重大科学研究计划（973），2013CB910203，亚纳米尺度表征蛋白质动态学的新技术新方法,
• 整合结构模拟研究化学修饰对生物大分子凝聚物相变过程的调控,进行,
• 计算机模拟整合冷冻电镜结构研究生物大分子复合物的组装,进行,
• 亚纳米尺度表征蛋白质动态学的新技术新方法-1,进行,