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影响因子：7.9

DOI码：10.1038/s41378-023-00603-2

发表刊物：Microsystems & Nanoengineering

摘要：Osmotic pressure is vital to many physiological activities, such as cell proliferation, wound healing and disease treatment. However, how cells interact with the extracellular matrix (ECM) when subjected to osmotic shock remains unclear. Here, we visualize the mechanical interactions between cells and the ECM during osmotic shock by quantifying the dynamic evolution of the cell traction force. We show that both hypertonic and hypotonic shocks induce continuous and large changes in cell traction force. Moreover, the traction force varies with cell volume: the traction force increases as cells shrink and decreases as cells swell. However, the direction of the traction force is independent of cell volume changes and is always toward the center of the cell-substrate interface. Furthermore, we reveal a mechanical mechanism in which the change in cortical tension caused by osmotic shock leads to the variation in traction …

第一作者：Yongman Liu

论文类型：期刊论文

通讯作者：Shangquan Wu,Qingchuan Zhang

卷号：9

期号：1

页面范围：131

是否译文：否

发表时间：2023-10-16

收录刊物：SCI

发布期刊链接：https://www.nature.com/articles/s41378-023-00603-2