中文

仓春蕾

E-Mail:

Administrative Position:基础医学院党总支书记

Degree:Dr

Basic Information
Scientific Research

Research Focus

[1] 溶酶体膜离子通道的特性、功能和调制

[2] 溶酶体及其他细胞器离子通道在胞内信号转导中的作用

[3] 细胞器离子通道相关疾病机理研究及作用于细胞器离子通道的新型药物开发

Papers

[1] 7. Xu SY, Cang CL, Liu XF, Peng YQ, Ye YZ, Zhao ZQ, Guo AK (2006) Thermal nociception in adult Drosophila: behavioral characterization and the role of the painless gene. Genes Brain Behav 5: 602–613.2021,

[2] 6. Zhang H., Cang CL, Kawasaki Y, Liang LL, Zhang YQ, Ji RR, Zhao ZQ (2007) Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCe: a novel pathway for heat hyperalgesia. J Neurosci 27: 12067-12077 .2021,

[3] 5. Cang CL, Zhang H, Zhang YQ, Zhao ZQ (2009) PKCepsilon-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons. Mol Pain 5:33.2021,

[4] 4. Cang, C.*, Bekele, B., Ren, D.*. (2014) The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nature Chemical Biology 10: 463-469 (*co-corresponding authors).2021,

[5] 3. Cang, C.*, Aranda, K., Ren, D.*. A non-inactivating high-voltage-activated two-pore Na+ channel that supports ultra-long action potentials and membrane bistability. Nature communications 5: 5015 (*co-corresponding authors).2021,

[6] 2. Cang, C., Zhou, Y., Navarro, B., Aranda, K., Shi, L., Battaglia-Hsu, S., Nissim, I., Clapham, D. and Ren, D. (2013) mTOR Regulates Lysosomal ATP-sensitive Two-Pore Na+ Channels to Adapt to Metabolic State. Cell 152: 778-790 .2021,

[7] 1. Cang, C., Aranda, K., Seo, YJ., Gasnier, B., Ren, D. (2015) TMEM175 is an Organelle K(+) Channel Regulating Lysosomal Function. Cell 162(5): 1101-12. Doi:10.1016/j.cell.2015.08.002.2021,

Research Project

[1] 溶酶体稳态平衡调控衰老的分子机制,进行,

[2] 溶酶体离子通道研究,进行,

[3] 溶酶体膜电位的调控和功能研究,进行,

[4] 溶酶体钾离子通道和氯离子通道的鉴定及功能研究,进行,

[5] 溶酶体离子通道在免疫细胞和肿瘤细胞中的表达分布和功能调控研究,进行,

[6] 溶酶体新型氨基酸转运体的筛选鉴定,进行,