非编码RNA在重大疾病中稳态调控的机制研究

1、非编码RNA生成、转运等基本RNA生物学进程的生理病理关联；

2、非编码RNA与RNA结合蛋白的互作的功能与机制

2、功能性非编码RNA在肿瘤及心血管疾病等人类重大疾病中调控稳态的机制

(1) Xiuzhi Li, Xiaolin Wang, Xu Liu, Ge Shan, Liang Chen, A UFD1 variant encoding a microprotein modulates UFD1f and IPMK ubiquitination to play pivotal roles in anti-stress responses, Nature Communications, 2025;16(1):6695.

(2) Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan*, Liang Chen*, Ying Zhou*, Tumor Exosome-Transmitted LncRNA CATED Promotes Platinum-Resistance in High-Grade Serous Ovarian Cancer, Advanced Science, 2025:e05963.

(3) Xu Liu#, Qinwei Wang#, Xinya Li, Yan Yang, Yuqi Deng, Xiaolin Wang, Peipei Wang, Liang Chen, Likun Ma, Ge Shan, Fast Degradation of MecciRNAs by SUPV3L1/ELAC2 Provides a Novel Opportunity to Tackle Heart Failure With Exogenous MecciRNA, Circulation, 2025, 151(17):1272-1290.

(4) Yanfei Liu#, Yucong Wang# , Yuqing Fei, Hu Xu, Cheng Xue, Liudong Li, Lei Huang, Pengcheng Liu, Renming Li, Ge Shan, Liang Chen*, Dahai Zhao*, Circular RNA FCHO2 promotes airway remodeling in COPD via regulating nuclear translocation of PTBP1 to repress the splicing of GRN pre-mRNA, Cell Death and Disease, 2025, 16(1):779

(5) Youbiao Heng, Zhicheng Yu, Liang Chen* and Ying Zhou*. Lactylation in Gynecological, Malignancies: A Bridge between Lactate Metabolism and Epigenetic Therapy. Oncology Advances, 2025. doi: 10.14218/OnA.2025.00020.

(6) Chenchen Zhu, Xuehan Liu, Hanjie Xu, Cheng Peng, Ying Peng, Bei Yao, Yuting Li, Yingying Wang, Liang Chen, Buyun Liu*, and Ying Zhou*, A cross-sectional study of 55,415 women validating the effect of age on serum CA125 levels, The Innovation Medicine, 2025, 3(3): 100147

(7) Yinchun Zhong^#, Yan Yang^#, Xiaolin Wang, Bingbing Ren, Xueren Wang*, Ge Shan^*, Liang Chen^*, Systematic identification and characterization of Exon-intron circRNAs, Genome Research, 2024, 34(3):376-393.

(8) Gui-Bin Gao^#, Liang Chen^#, Jia-Feng Pan, Tao Lei, Xin Cai, Zhexue Hao, Qi Wang, Ge Shan, Jin Li*, LncRNA RGMB-AS1 inhibits HMOX1 ubiquitination and NAA10 activation to induce ferroptosis in non-small cell lung cancer, Cancer Letters, 2024, 216826.

(9) Hanyuan Liu, Sisi Deng, Xuelin Yao, Yi Liu, Lili Qian, Yingying Wang, Tianjiao Zhang, Ge Shan*, Liang Chen*, Ying Zhou*, Ascites exosomal lncRNA PLADE enhances platinum sensitivity by inducing R-loops in ovarian cancer, Oncogene, 2024, 43(10):714-728.

Hong Wu, Yiqiang Liu, Qianshi Liu, Zhaoshen Li, Yejian Wan, Chenhui Cao, Binghuo Wu, MingXin Liu, Renchuan Liang, Lanlin Hu, Wenyi Zhang, Mei Lan, Quan Yao, Hang Zhou, Haitao Lan, Liang Chen, Yu Zhang, Xia Zhang, Xiu-Wu Bian*, Chuan Xu*, HMMR triggers immune evasion of hepatocellular carcinoma by inactivation of phagocyte killing, Science Advances, 2025, 10(23):eadl6083.

(10) Shuhui Chang^#, Yucong Wang^#, Xiaolin Wang, Hanyuan Liu, Tao Zhang, Yangge Zheng, Xueren Wang, Ge Shan^*, Liang Chen^*, HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes, RNA Biology, 2024, 21(1):1-15.

(11) Yan Yang^#, Yinchun Zhong^#, Liang Chen^*, EIciRNAs in focus: current understanding and future perspectives, RNA Biology, 2024, 22:1, 1-12

(12) Xu Liu#, Xuelin Yao#, Liang Chen, Expanding roles of circRNAs in cardiovascular disease, Non-coding RNA Research, 2024, 9(2):429-436

(13) Hanyuan Liu, Xuelin Yao, Ying Zhou*, Liang Chen*, CircRNA-based therapeutics: Current opinions and clinical potential, The Innovation Medicine, 2024, 2(3): 100081

(14) Xuelin Yao^#, Hanyuan Liu^#, Zhen Wang, Fangting Lu, Wenying Chen, Qing Feng, Yahu Miao, Jie Zhang, Yanlei Wang, Ye Chen, Liping Xue, Yehai Liu, Liang Chen^*, Qiu Zhang^*, Circular RNA EIF3I promotes papillary thyroid cancer progression by interacting with AUF1 to increase Cyclin D1 production, Oncogene, 2023, 42(43):3206-3218.

(15) Hong Wu#, Xuefeng Leng#, Qianshi Liu#, Tianqin Mao# , Tao Jiang# , Yiqiang Liu, Feifei Li, Chenhui Cao, Jun Fan, Liang Chen, Yaqi Chen, Quan Yao, Shun Lu , Renchuan Liang, Lanlin Hu, Mingxin Liu, Yejian Wan, Zhaoshen Li, Jun Peng, Qiyu Luo, Hang Zhou, Jun Yin, Ke Xu, Mei Lan, Xinhao Peng, Haitao Lan, Gang Li, Yongtao Han, Xia Zhang, Zhi-Xiong Jim Xiao, Jinyi Lang, Guihua Wang*, Chuan Xu*, Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma, Cancer Research, 2023, 83(18):3131-3144.

(16) Wanying Sun, Changming Zhou, Caiqiu Peng, Ran Yang, Mengting Li, Jian Geng, Jihong Zhou, Liang Chen, Wei Li , Diagnostic value of plasma circular RNA based on droplet digital polymerase chain reaction in lung adenocarcinoma, Lab Medicine, 55(4):420-432.

(11) Sisi Deng; Lili Qian; Luwen Liu; Hanyuan Liu; Zhihao Xu; Yujie Liu; Yingying Wang; Liang Chen^*; Ying Zhou^*; Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1, Cancer Science, 2023, 114(4):1582-1595

(17) Wenying Chen, Hanyuan Liu, Xinya Huang, Lili Qian, Liang Chen, Yonggang Zhou, Yi Liu, Yujie Liu, Yingying Wang, Tianjiao Zhang, Youyang Zhou, Jingwen Fang, Jiaxuan Yang, Fang Ni, Chuang Guo, Ying Zhou, A single-cell landscape of pre- and post-menopausal high-grade serous ovarian cancer ascites, iScience, 2023, 26(10):107712.

(18) Kewei Zhang; Ge Shan*; Liang Chen*; Modulating miRNA binding sites within circRNA for enhanced translation efficiency, JUSTC（中国科学技术大学学报）, 2023, 53(9)

(19) Liang Chen^#; Yucong Wang^#; Jiamei Lin; Zhenxing Song; Qinwei Wang; Wenfang Zhao; Yan Wang; Xiaoyu Xiu; Yuqi Deng; Xiuzhi Li; Qiqi Li; Xiaolin Wang; Jingxin Li; Xu Liu; Kunpeng Liu; Jincong Zhou; Kuan Li; Yuchan Liu; Shanhui Liao; Qin Deng; Chao Xu; Qianwen Sun; Shengzhou Wu; Kaiming Zhang; Min-Xin Guan; Tianhua Zhou; Fei Sun; Xiujun Cai; Chuan Huang^*; Ge Shan^*; Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs, Nature Communications, 2022, 13(1): 5769

(20) Liang Chen, Chuan Huang^*, Ge Shan^*; Circular RNAs in physiology and non-immunological diseases, Trends in Biochemical Sciences, 2022, 47(3): 250-264

(21) Pengcheng Liu^#; Yucong Wang^#; Ningning Zhang; Xiaomin Zhao; Renming Li; Yu Wang; Chen Chen; Dandan Wang; Xiaoming Zhang; Liang Chen^*; Dahai Zhao^*; Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease., Respiratory Research, 2022, 23(1): 154-154

(22) Liang Chen*, Ge Shan*, CircRNA in cancer: Fundamental mechanism and clinical potential, Cancer Letters, 2021,18;505:49-57.

(23) Liu Hanyuan; Zhu Chenchen; Xu Zhihao; Wang Juan; Qian Lili; Zhou Qingqing; Shen Zhen; Zhao Weidong; Xiao Weihua; Chen Liang^*; Zhou Ying^*; lncRNA PART1 and MIR17HG as δNp63 alpha direct targets regulate tumor progression of cervical squamous cell carcinoma, Cancer Science, 2020, 111(11): 4129-4141

(24) Liuze Gao#, Shuhui Chang#, Wenjuan Xia, Xiaolin Wang, Chenwang Zhang, Liping Cheng, Xu Liu, Liang Chen, Qinghua Shi, Juan Huang, Eugene Yujun Xu*, Ge Shan*, Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline. Science Advances, 2020, 6(46):eabb7426.

(25) Ying Zhou^#; Hanyuan Liu^#; Juan Wang; Xiaolin Wang; Lili Qian; Fei Xu; Weiguo Song; Dabao Wu; Zhen Shen; Dingqing Feng; Bin Ling; Weihua Xiao; Ge Shan^*; Liang Chen^*; ΔNp63α exerts antitumor functions in cervical squamous cell carcinoma, Oncogene, 2019, 39: 905-921

(26) Zhiyong Sheng, Xiaolin Wang, Geliang Xu*, Ge Shan*, Liang Chen*, Analyses of a panel of transcripts identified from a small sample size and construction of RNA networks in hepatocellular carcinoma, Frontiers in Genetics, 2019, 10:431.

(27) Liang Chen*, Emmanuel Enoch Dzakah, Ge Shan*, Targetable long non-coding RNAs in cancer treatments, Cancer Letters, 2018, 418, 119–124.

(28) Hassaan M Awan#, Abdullah Shah#, Farooq Rashid#, Shuai Wei, Liang Chen*, Ge Shan*, Comparing two approaches of miR-34a target identification, biotinylated-miRNA pulldown vs miRNA overexpression. RNA Biology, 2018(15): 55-61.

(29) Abdullah Shah#, Farooq Rashid#, Hassaan M Awan#, Shanshan Hu, Xiaolin Wang, Liang Chen*, Ge Shan*, The DEAD-Box RNA Helicase DDX3 Interacts with m(6)A RNA Demethylase ALKBH5. Stem Cells International, 2017, 10.1155/ 2017/ 8596135.

Farooq Rashid, Hassaan Mehboob Awan, Abdullah Shah, Liang Chen, Ge Shan, Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation,  International  Journal of Molecular Sciences. 2017 Jun 29;18(7):1375. 

(30) 陈亮，单革*, 非编码RNA研究综述. 科学通报, (2017) 62 (27), 3236-3244  (科学通报：Science125个科学前沿问题系列解读)

(31) 陈亮，单革*,非编码RNA功能与功能机理研究. 中国科学：生命科学, 2017, 47: 36-42.

(32) Zhaoyong Li, Chuan Huang, Chun Bao, Liang Chen, Mei Lin, Xiaolin Wang, Guolin Zhong, Bin Yu, Wanchen Hu, Limin Dai, Pengfei Zhu, Zhaoxia Chang, Qingfa Wu, Yi Zhao, Ya Jia, Ping Xu, Huijie Liu, Ge Shan,  Exon-intron circular RNAs regulate transcription, Nature Structural & Molecular Biology, 2015, 22(3):256-64

(33) Liang Chen, Farooq Rashid, Abdullah Shah, Hassaan M Awan, Mingming Wu, An Liu, Jun Wang, Tao Zhu, Zhaofeng Luo, Ge Shan*, The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation, Proceedings of National Academy of Sciences U S A (PNAS), 2015, 112(32):10002-10007.

(34) Liang Chen, Ge Shan*, Circular RNAs remain peculiarly unclear in biogenesis and function，Science China Life Sciences, 2015, 58(6):616-618.

(35) Liang Chen, Chuan Huang, Xiaolin Wang, Ge Shan*, Circular RNAs in Eukaryotic Cells, Current Genomics, 2015, 16(5) :312-318.

(36) Limin Dai, Chuan Huang, Liang Chen, Ge Shan, Zhaoyong Li, Altered expression of microRNAs in the response to ER stress, Science Bulletin, 2015, 60(2), 202-209

(37) Lingfeng Meng, Liang Chen, Zhaoyong Li, Zheng-Xing Wu, Ge Shan, Roles of microRNAs in the Caenorhabditis elegans nervous system, Journal of Genetics and Genomics, 2013,  40(9):445-52. 

(38) Lingfeng Meng, Liang Chen, Zhaoyong Li, Zhengxing Wu, Ge Shan, Environmental RNA interference in animals, Chinese Science Bulletin, 2013, 58(35), 4418-4425

(39) Shanshan Hu, Jing Wu, Liang Chen, Ge Shan. Signals from noncoding RNAs: unconventional roles for conventional pol III transcripts.International Journal of Biochemistry and Cell Biology. 2012;44(11):1847-1851.