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影响因子：11.41

DOI码：10.1073/pnas.2207693119

发表刊物：Proc. Natl. Acad. Sci. U.S.A.

摘要：Although the onset time of chemical reactions can be manipulated by mechanical, electrical, and optical methods, its chemical control remains highly challenging. Herein, we report a chemical timer approach for manipulating the emission onset time of chemiluminescence (CL) reactions. A mixture of Mn2+, NaHCO3, and a luminol analog with H2O2 produced reactive oxygen species (ROS) radicals and other superoxo species (superoxide containing complex) with high efficiency, accompanied by strong and immediate CL emission. Surprisingly, the addition of thiourea postponed CL emission in a concentration-dependent manner. The delay was attributed to a slow-generation-scavenging mechanism, which was found to be generally applicable not only to various types of CL reagents and ROS radical scavengers but also to popular chromogenic reactions. The precise regulation of CL kinetics was further utilized in dynamic chemical coding with improved coding density and security. This approach provides a powerful platform for engineering chemical reaction kinetics using chemical timers, which is of application potential in bioassays, biosensors, CL microscopic imaging, microchips, array chips, and informatics.

合写作者：聂威,于璐,舒江南,李耀华,田长麟

第一作者：郑天骅

论文类型：期刊论文

通讯作者：崔华,王伟

学科门类：理学

文献类型：J

卷号：119

期号：43

页面范围：e2207693119

是否译文：否

发表时间：2022-10-17

收录刊物：SCI

发布期刊链接：https://www.pnas.org/doi/10.1073/pnas.2207693119#bibliography