Scientific Research

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Paper Publications

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• Wang C#, Wei Z#, Chen K, Ye F, Yu C, Bennett V, and Zhang M*. (2014). Structural basis of diverse membrane target recognitions by ankyrins. eLife. 3:e04353..2021,
• Lorenzo DN, Healy JA, Hostettler J, Davis J, Yang J, Wang C, Hohmeier HE, Zhang M, and Bennett V. (2015). Ankyrin-B metabolic syndrome: age-dependent adiposity combined with primary pancreatic beta-cell insufficiency. J Clin Invest. 125(8):3087-3102..2021,
• Chen K#, Li J#, Wang C, Wei Z, and Zhang M. (2017). Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions. eLife. 6:e29150..2021,
• Wang C, Yu C, Ye F, Wei Z*, and Zhang M*. (2012). Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function. PNAS. 109 (13):4822-4827..2021,
• Jiang H#, He H#, Chen Y#, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W*, Deng X*, and Zhou R*. (2017). Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 214(11):3219-3238..2021,
• Zhu W#, Wang C#, Hu J#, Wan R, Yu J, Xie J, Ma J, Guo L, Ge J, Qiu Y, Chen L, Liu H, Yan X, Liu X, Ye J, He W, Shen Y, Wang C, Mohler PJ*, and Hong K*. (2018). Ankyrin-B Q1283H variant linked to arrhythmias via loss of local protein phosphatase 2A activity causes ryanodine receptor hyperphosphorylation. Circulation. 138(23):2682-2697..2021,

Patents

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Published Books

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Research Projects

• 蛋白质机器相变在神经突触形成、成熟及功能中的作用,进行,
• m6A RNA甲基转移酶复合物组装的分子机制研究,进行,
• Ankyrin-G/E-cadherin复合物对表皮细胞侧膜构架的生化结构研究,进行,
• 对神经细胞轴突起始段中支架蛋白Ankyrin-G介导的蛋白复合物的结构与功能研究,进行,
• E-cadherin复合物对表皮细胞侧膜构架及细胞极性维持的分子机制研究,进行,
• 神经细胞轴突起始段组织构架的结构生物学研究,进行,