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    李博峰

    • 研究员 博士生导师 硕士生导师
    • 电子邮箱:
    • 学历:博士研究生毕业
    • 办公地点:科大中校区医学楼309
    • 联系方式:电话:0551-63606859 Email:libf@ustc.edu.cn
    • 学位:理学博士学位
    • 毕业院校:中国科学技术大学
    • 学科:生物学

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    科学研究

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    1. Gong F, Zhang Q, Qian J, He Y, Du K, Fang H, Li Q, Yang Y, Wei HX, Jin T*, Wang Y*, Bofeng Li*. Trans-presentation of IL-6Rα by macrophages drives colorectal cancer development. Cell Rep. 2026 Jun 19;45(7):117549.

     

    2. Chen G, Li X, Huang Y, Zheng C, Fang H, Zhang Q, Liu K, Wu K, Zhu Q, Guo C, Zhu H, Dai R, He Y, Zhu Q, Zhou W, Yang Y, Li Z, Qu K*, Bofeng Li*, Xiao S*, Tian S, Xing B, Chen X, Wang AZ, Xiong Y, Min Y*. X-ray activated platinum complex induces DNA damage and enhances cancer immunotherapy through abscopal effect. Nat Biomed Eng. 2026 Feb 9. Online ahead of print.

     

    3. Li W, Liu Y, Wei M, Yang Z, Li Z, Guo Z, Yan L, Lu Y, Tang H, Bofeng Li*, Huang W*. Functionalized Biomimetic Nanoparticles Targeting the IL-10/IL-10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis. Adv Sci (Weinh). 2025 Jul;12(27):e2504768.

     

     

    4. Shimu AS, Wei HX, Li Q, Zheng X, Bofeng Li*. The new progress in cancer immunotherapy. Clin Exp Med. 2023 Jul;23(3):553-567.

     

    5. Huang W, Tang H, Liu Y, Li W, Shimu AS, Bofeng Li*, Zhu C*. ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.

    Int Immunopharmacol. 2023 Aug;121:110433.

     

    6. Cong M, Yang Y, Tong H, Shimu AS, Wang B, Li Q, Li F, Yang Y, Jin T*, Bofeng Li*. 3-dose of RBD vaccine is sufficient to elicit a long-lasting memory response against SARS-CoV-2 infection. Signal Transduct Target Ther. 2022;7(1):84.

     

    7. Gong F, Wei HX, Qi J, Ma H, Liu L, Weng J, Zheng X, Li Q, Zhao D, Fang H, Liu L, He H, Ma C, Han J, Sun A, Wang B, Jin T*, Li B*, Bofeng Li*. “Pulling-Force Spinning Top for Serum Separation Combined with Paper-Based Microfluidic Devices in COVID-19 ELISA Diagnosis.“ ACS Sensors. 2021, 6:2709-2719.

     

    8. Xu Z, Zhou Y, Liu M, Ma H, Sun L, Zahid A, Chen Y, Zhou R, Cao M, Wu D, Zhao WBofeng Li*, Jin T*. “Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome.” Cell Death Dis. 2021;12:57.

     

    9. Wei HX, Wang B, Bofeng Li*. “IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology. Front Immunol. 2020 ;11:1315.

     

    10. Zahid A, Ismail H, Bofeng Li*, Jin T*. “Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity. Front Immunol. 2020 ;11:613039.

     

    11. Koelink PJ , Bloemendaal FM, Bofeng Li, Westera L, Vogels EM, van RM, Gloudemans AK, van 't Wout AB, Korf H, Vermeire S, Velde AA, Ponsioen CY, D'Haens GR, Verbeek JS, Geiger TL, Wildenberg ME, van den Brink GR. “Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling.” Gut. 2020 69:1053-1063.

     

    12. Bofeng Li, Jones LL, Geiger TL. “IL-6 Promotes T Cell  Proliferation and Expansion under Inflammatory Conditions in Association with Low-Level RORgammat Expression.”Journal of Immunology. 2018. 201:2934-2946.

     

    13. Jones LL, Alli R, Bofeng Li, Geiger TL.“Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.”Journal of Immunology. 2016. 196:2973-2985.

     

    14. Zhao Y, Nguyen P, Vogel P, Bofeng Li, Jones LL, Geiger TL. “Autoimmune susceptibility imposed by public TCRβ chains.” Scientific Reports. 2016. 21:37543.

     

    15. Bofeng Li, Gurung P, Malireddi RK, Vogel P, Kanneganti TD, Geiger TL.“IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis.” Nature Communications. 2015. 6:6131.

     

    16. Gurung P, Bofeng Li, Malireddi RK, Lamkanfi M, Geiger TL, Kanneganti TD.“Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation.” Scientific Reports. 2015. 5:14488.

     

    17. Bofeng Li, Alli R, Vogel P, Geiger TL.“IL-10 modulates DSS-induced colitis through a macrophage-ROS-NO axis.”Mucosal Immunology. 2014. 7:869-878.

     

    18. Tauro S, Nguyen P, Bofeng Li, Geiger TL.“Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis.”European Journal of Immunology. 2013. 43:1195-1207.

     

    19. Savage AK, Constantinides MG, Han J, Picard D, Martin E, Bofeng Li, Lantz O, Bendelac A.“The transcription factor PLZF directs the effector program of the NKT cell lineage.”Immunity. 2008. 29:391-403.

     

    20. Wei HX, Chuang YH, Bofeng Li, Wei H, Sun R, Moritoki Y, Gershwin EM, Lian ZX, Tian Z.“CD4+CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-beta-dependent manner in mice.”Journal of Immunology. 2008. 181:7221-7229.

     

    21. Bofeng Li, Sun R, Wei H, Gao B, Tian Z.“Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism.” Hepatology. 2006.