主要研究方向：

（1）基于化学生物学方法研究神经系统疾病、肿瘤等重大疾病相关膜蛋白的动态构象机制

（2）发展¹⁹F核磁共振波谱学方法研究大分子量蛋白质动态特性

（3）重要疾病相关蛋白的创新型药物设计和筛选

 近五年代表性论著：

1.     Bo Q^#, Zhang MG^#, Yang F^#, Zheng Y, Li ZL, Zheng YM, Wu FM, Liang J, Zhou L, Li DS, Wu Y, Tian C^*, Lv P^*, Shi P^*. Somatostatin receptor 2 targeting peptide modifications for peptide-drug conjugate treatment of small cell lung cancer. Acta Pharmacol Sin. 2025. 0:1–11；doi: 10.1038/s41401-025-01584-w.

2.    Li Z^#, Zhang Y^#, Liang J^#, Jia F, Song J, Sun D, Shi C^*, Tian C^*, Shi P^*. Solution NMR Analysis Reveals Synergistic β-Arrestin1 Activation by Chemically Synthesized Phosphopeptides of a C-Terminal Tail and ICL3 of NTSR1. ACS Chem Biol. 2025. 20(7):1464-1469.

3.     Zhang Y^#, Zhu Y^#, Zhang Y^#, Shi C, Zhang L, Liang J*, Tian C*, Shi P*. ¹⁹F NMR chemical shift encoded peptide screening targeting the potassium channel Kv1.3. Chemical Communications. 2025;61(33):6162-6165.

4.     Zhang H^#, Wang R^#, Shi P^#*, Gaoming Wang, Qingjun Zhu, Xinheng He,Youwei Xu, Qingning Yuan, Wen Hu, Kai Wu, Yong Zheng, Li Zhou, Jun Liang, Pei Lv, Ziyan Xu, Fan Yang, Yingbin Liu, Youwen Zhuang, H. Eric Xu*, Yue Wang*, Changlin Tian*, Rational design of a kappa opioid receptor peptide agonist with attenuated β-arrestin signaling, Nature Commun. 2026, 17(1):5439.

5.     Ling S^#*, Meng X^#, Zhang Y^#, Xia Z, Zhou Y, Yang F, Shi P^*, Shi C^*, Tian C^*. Structural insights into asymmetric activation of the calcium-sensing receptor-Gq complex. Cell Research. 2024;34(2):169-172.

6.     Li YG, Meng XY, Yang X, Ling SL, Shi P^*, Tian CL^*, Yang F^*. Structural insights into somatostatin receptor 5 bound with cyclic peptides. Acta Pharmacol Sin. 2024 (11):2432-2440.

7.     Zhao R^#,Shi P^#, Cui JB^#, Shi C^*, Wei XX, Luo J, Xia Z, Shi WW, Zhou Y, Tang J, Tian C, Meininghaus M, Bierer D, Shi J^*, Li YM^*, Liu L^*. Single-Shot Solid-Phase Synthesis of Full-Length H2 Relaxin Disulfide Surrogates. Angew Chem Int Ed Engl. 2023;62(6):e202216365

8.     Sun W^#, Yang F^#, Zhang H^#, Yuan Q^#, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W*, Shi P*, Xu HE*, Tian C*. Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists. Cell Discovery. 2023 ;9(1):66.

9.    Yang F^#, Zhang H^#, Meng X^#, Li Y, Zhou Y, Ling S, Sun D, Lv P, Liu L^*, Shi P^*, Tian C^*. Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue. Cell Research. 2022; 32(9):858-861.

10. Fang W^#, Yang F^#, Xu C^#, Ling S^#, Lin L, Zhou Y, Sun W, Wang X, Liu P, Rondard P, Shi P^*, Pin JP^*, Tian C^*, Liu J^*. Structural basis of the activation of metabotropic glutamate receptor 3, Cell Research, 2022;32(7):695-698.

11. Sun W^#, Yuan Q^#, Zhang H^#, Yang F, Ling S, Luo Y, Lv P, Eric Xu H^*, Tian C^*, Yin W^*, Shi P^*. Structural insights into the activation of neurokinin 2 receptor by neurokinin A. Cell Discovery. 2022;8(1):72.

12.  Bo Q^#, Yang F^#, Li Y^#, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L^*, Shi P^*, Tian C^*. Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discovery. 2022;8(1):47. doi: 10.1038/s41421-022-00405-2.

13.  Li L, Zhang J, Sun W, Gong W, Tian C, Shi P^∗, Shi C^*, Allosteric conformational changes of G proteins upon its interaction with membrane and GPCR, Chinese Chemical Letters 2022, 33, 747–750.

14. Ling S^#, Shi P^#, Liu S^#, Meng X^#, Zhou Y, Sun W, Chang S, Zhang X, Zhang L, Shi C, Sun D^*, Liu L^*, Tian C^*. Structural Mechanism of the Human Calcium-Sensing Receptor Cooperatively Activated by Ca²⁺ Ions and L-tryptophan. Cell Research. 2021, 31, 383–394.

15. Yang F^#, Ling S^#, Zhou Y^#, Zhang Y, Lv P, Liu S, Fang W, Sun W, Hu LA, Zhang L, Shi P^*, Tian C*. Different Conformational Responses of the b2-Adrenergic Receptor-Gs Complex upon Binding of the Partial Agonist Salbutamol or the Full Agonist Isoprenaline. National Science Review. 2020. 8(9)

16. Zhang Y^#, Yang F^#, Ling S^#, Lv P, Zhou Y, Fang W, Sun W, Zhang L, Shi P^*, Tian C^*. Single-particle cryo-EM structural studies of the β2AR-Gs complex bound with a full agonist formoterol. Cell Discovery. 2020; 6:45.

17.  Shi P^#*, Zhang Y^#, Lv P^#, Fang W, Ling S, Guo X, Li D, Liu S, Sun D, Zhang L, Liu D, Zheng JS, Tian C^*. A genetically encoded small-size fluorescent pair reveals allosteric conformational changes of G proteins upon its interaction with GPCRs by fluorescence lifetime based FRET, Chemical Communications. 2020, 56(51):6941-6944.

18.  Zhao R^#, Shi P^#, Chen J^#, Sun S, Chen J, Cui J, Wu F, Fang G, Tian C, Shi J^*, Bierer D, Liu L^*, Li YM^*. Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond, Chemical Science, 2020, 11, 7927–7932.