tangaihui
- Professor
- Supervisor of Doctorate Candidates
- Supervisor of Master's Candidates
- Name (English):Ai-Hui Tang
- Name (Pinyin):tangaihui
- E-Mail:
- Degree:Dr
- Professional Title:Professor
- Academic Titles:Professor
- Alma Mater:Peking University
- Teacher College:Life Sciences
Contact Information
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- Scientific Research
Our research bridges nanoscale synapse biology and large‑scale spatial omics. At the synaptic level, his lab focuses on the structural mechanisms underlying synaptic transmission and plasticity using single-molecule super-resolution imaging. Key contributions include the discovery of trans‑synaptic nanocolumns. At the systems level, his group has developed a series of imaging‑based spatial multi-omics technologies, enabling subcellular resolution mapping of thousands of gene targets across centimeter-scale brain sections.
Our current research focuses on two interlinked directions:
(1) dissecting the nanoscale structure–function relationships of synapses and their dysregulation in neurological disorders using MINFLUX and other super‑resolution techniques;
(2) developing spatial multi‑omics imaging technologies and the MetaScope platform for high‑throughput, subcellular‑resolution mapping of large tissue sections, with applications in brain-wide circuit analysis and pathology.
Publications (Selected from 49) * Co-first author, # Corresponding author
1. Lin J*, Chen C*, Li S#, Chen L, Fang M, Fu S, Chen K, Xu H, Zhang F, Wang R, Jiang C, Tang M, Liu Z, Wang S, Liu K, Niu C, Li B, Liu X, Cheng C#, Tang AH#, Qu K# (2026) Multi-omics analysis characterizes the spatial architecture of glioblastoma ecosystems. Nat Neurosci. In press.
2. Ke W, Lyu S, Jin M, Jiao S, Li L, Zhang H, Ling K, Tian C, Song Y, Chen L, He O, Xiao YJ, Deng S, Fan L, Mu H, Yang H, Xu H, Wang H, Tang A, Peng J, He J, Guo H, Shu Y (2026) Spindle neurons in human cortex possess distinctive firing properties and transcriptomic signatures. Nat Commun. In Press.
3. Chen L, Teng X#, Tang AH# (2026) GLASS-seq: a gel-anchored, ligation-assisted, scalable biosensing platform for low-cost regional spatial transcriptomics. Biosens. Bioelectron. 311: 118973.
4. Lin JK, Liu Y, Deng J, Wang HL, Li Q, Chen L, Ding WQ, Tang AH, Dou YN#, Sun YG# (2026) Transcriptomic and spatial organization of mouse spinal cord projection neurons. Cell Rep. 45(1):116717.
5. Gu W*, Chen JH*, Zhang Y*, Wang Z*, Li J*, Wang S, Zhang H, Jiang A, Zhong Z, Zhang J, Xu Z, Liu P, Xi C, Hou T, Gill DL, Li D, Mu Y#, Wang SQ#, Tang AH#, Wang Y# (2025) Highly dynamic and sensitive NEMOer calcium indicators for imaging ER calcium signals in excitable cells. Nat Commun. 16, 3472.
6. Xu N*#, Chen SY*, Tang AH# (2025) Tuning synapse strength by nanocolumn plasticity. Trends Neurosci. 48(3):200-212.
7. Yan HH, He JJ, Fu C, Chen JH#, Tang AH# (2025) ATAD1 regulates neuronal development and synapse formation through tuning mitochondrial function. Int. J. Mol. Sci. 26(1):44.
8. Sun SY, Nie LY, Fang X, Luo HM, Fu C#, Wei Z#, Tang AH# (2025) The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons. Neural Regen Res. 20(1):209-223.
9. Chen JH#, Tang AH# (2024) Nanoscale reorganization of glutamate receptors underlies synaptic plasticity and pathology. Neurosci Bull. 40:840–844.
10. Xu N*, Cao R*, Chen SY, Gou XZ, Wang B, Luo HM, Gao F, Tang AH (2024) Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2. Proc. Natl. Acad. Sci. U.S.A., 121(18): e2314541121.
11. Chen JH*#, Xu N*, Qi L, Yan HH, Wan FY, Gao, F, Fu C, Cang C, Lu B, Bi GQ, Tang AH# (2023) Reduced lysosomal density in neuronal dendrites mediates deficits in synaptic plasticity in Huntington’s disease. Cell Rep, 42(12): 113573.
12. He J, Liu K, Wu Y, Zhao C, Yan S, Chen JH, Hu L, Wang D, Zheng F, Wei W, Xu C, Huang C, Liu X, Yao X, Ding L, Fang Z#, Tang AH#, Fu C# (2023) The AAA-ATPase Yta4/ATAD1 interacts with Dnm1 and Fis1 to inhibit mitochondrial fission. Plos Bio., 21(8): e3002247.
13. Li D, Cao R, Li Q, Yang Y, Tang AH, Zhang J, Liu Q (2023) Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment. Nat Struct Mol Biol, 30(7):914-925.
14. Li J*, Shang Z*, Chen JH* , Gu W*, Yao L*, Yang X, Sun X, Wang L, Wang T, Liu S, Li J, Hou T, Xing D, Gill DL, Li J, Wang SQ, Hou L, Zhou Y#, Tang AH#, Zhang X#, Wang Y# (2023) Engineering of NEMO as calcium indicators with large dynamics and high sensitivity. Nat Methods, 20: 918–924.
15. Zhu WH, Yang XX, Gou XZ, Fu SM, Chen JH, Gao F, Shen Y, Bi D#, Tang, AH# (2023) Nanoscale reorganisation of synaptic proteins in Alzheimer's disease. Neuropathol. Appl. Neurobiol. 49(4):e12924.
16. Han Y*, Cao R*, Qin L, Chen LY, Tang AH#, Südhof TC#, Zhang B# (2022) Neuroligin3 confines AMPA receptors in nanoclusters and controls synaptic strength at the calyx of Held. Sci Adv., 8(24): eabo4173.
17. Gou XZ*, Ramsey AM*#, Tang AH# (2022) Re-examination of the determinants of synaptic strength from the perspective of superresolution imaging. Curr Opin Neurobiol, 74:102540.
18. Ramsey A*, Tang AH*, LeGates TA, Gou XZ, Carbone BE, Thompson SM, Biederer T and Blanpied TA (2021) Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength. Sci Adv. 7(34): eabf3126.
19. Tang AH*#, Chen H*, Li TP, Metzbower SR, Mac Gillavry HD and Blanpied TA# (2016) A transsynaptic nanocolumn aligns neurotransmitter release to receptors. Nature. 536: 210–214.