主要研究方向
1、单碱基分辨的核酸成像分析与空间组学技术
2、核酸生命过程的化学生物学调控工具与应用
3、基于临床样本队列的疾病表观遗传机制解析
已发表论文
1. Teng, X., Zhang, Q., Dai, Y., Hou, H., and Li, J.* (2025). Chemical-assisted analysis of epigenetic modifications. Chemical Society Reviews.
2. Wang, J., Zhang, W., Li, S., Shi, W., Li, B., Zhang, J., Liang, Y.*, Teng, X.*, and Zhang, K.*(2025). RNA Editing-Mediated Correction of TP53 Nonsense Mutations via Lipid Nanoparticle-Delivered Circular ADAR-Recruiting RNAs. Journal of the American Chemical Society 147, 18512-18523.
3. Teng, X., Zhao, X., Dai, Y., Zhang, X., Zhang, Q., Wu, Y., Hu, D., and Li, J.* (2024). ClickRNA-PROTAC for Tumor-Selective Protein Degradation and Targeted Cancer Therapy. Journal of the American Chemical Society 146, 27382-27391.
4. Zhang, Q., Dai, Y., Teng, X.*, and Li, J.* (2024). Visualization and Quantification of Single‐Base m6A Methylation. Angewandte Chemie International Edition 64, e202420977.
5. Teng, X., Hu, D., Dai, Y., Jing, H., Hu, W., Zhang, Q., Zhang, N., and Li, J.* (2024). Discovery of A G‐Quadruplex Unwinder That Unleashes the Translation of G‐Quadruplex‐Containing mRNA without Inducing DNA Damage. Angewandte Chemie International Edition 63, e202407353.
6. Dai, Y.#, Teng, X.#, and Li, J.* (2021). Single‐Cell Visualization of Monogenic RNA G‐quadruplex and Occupied G‐quadruplex Ratio through a Module‐Assembled Multifunctional Probes Assay (MAMPA). Angewandte Chemie International Edition 61, e202111132.
7. Dai, Y.#, Teng, X.#, Zhang, Q., Hou, H.*, and Li, J.* (2023). Advances and challenges in identifying and characterizing G-quadruplex–protein interactions. Trends in Biochemical Sciences 48, 894-909.
8. Teng, X., Dai, Y., Li, K., Wu, Y., Hou, H.*, and Li, J.* (2023). LiveG4ID‐Seq for Profiling the Dynamic Landscape of Chromatin G‐Quadruplexes During Cell Cycle in Living Cells. Small Methods 7.
9. Dai, Y.#, Teng, X# Hu, D., Zhang, Q., and Li, J.* (2024). Evolution of Monkeypox C9L RNA G-Quadruplex Elevates the Translation of Its Only Kelch-like Protein by Accelerating G-Quadruplex Unfolding Kinetics. CCS Chemistry 6, 953-963.
10. Teng, X., Dai, Y., and Li, J.* (2022). Methodological advances of bioanalysis and biochemical targeting of intracellular G‐quadruplexes. Exploration 2.
11. Teng, X.#, Dai, Y.#, and Li, J.* (2022). Module Assembly Strategy for Single‐Cell Nucleic Acid Imaging at the Sub‐Molecule Level. Chemistry – A European Journal 28, e202104628.
发明专利
1. 李景虹; 滕续聪; 戴依聪，一种小分子-DNA相互作用图谱测序方法以及试剂盒，专利类型：发明授权，申请(专利)号： CN202310855906.0，申请日：2023-07-13，授权公告日：2023-10-20
2. 李景虹; 滕续聪; 胡迪斐; 戴依聪，一种核酸G-四链体解旋剂及应用，专利类型：发明授权，申请(专利)号：CN202410789676.7，申请日：2024-06-19，授权公告日：2024-08-20
3. 李景虹; 滕续聪; 戴依聪，一种高效染色质DNA结合图谱测序方法，专利类型：发明公开，申请(专利)号：CN202310031360.7，申请日：2023-01-10，申请公布日：2023-06-06
4. 李景虹; 滕续聪，一种用于实时监控细胞表观转录的融合蛋白，专利类型：发明公开，申请(专利)号：CN202311542779.5，申请日：2023-11-17，申请公布日：2024-04-02
5. 李景虹; 滕续聪，一种靶病毒的免扩增检测方法及试剂盒，专利类型：发明公开，申请(专利)号：CN202311723797.3，申请日： 2023-12-14，申请公布日：2024-04-12
6. 李景虹; 滕续聪; 赵轩; 戴依聪; 章秋爽，基于mRNA与点击化学分子的肿瘤特异性蛋白靶向降解剂及应用，专利类型：发明公开，申请(专利)号：CN202410727029.3，申请日：2024-06-06，申请公布日：2024-09-27
7. 李景虹; 侯宏卫; 滕续聪; 戴依聪; 胡迪斐，一种促进小胶质细胞向M2表型转化的药物筛选系统及其构建方法和应用，专利类型： 发明公开，申请(专利)号：CN202411014513.8，申请日：2024-07-26，申请公布日：2024-11-08
科研项目
1. 2023.08-2024.07，中国博士后科学基金面上项目，循环肿瘤 DNA G-四链体作为肝癌标志物的分子机制与早期诊断试剂盒开发，8万元，主持，结题
2. 2022.11-2025.10，国家重点研发计划，基于集成生物光电子技术的单分子测序的关键技术，30万元（1500万元），参与，在研
