NK细胞功能紊乱与临床干预策略研究

主要聚焦于NK细胞功能紊乱与临床干预策略研究，尤其关注NK细胞免疫监视功能受损在疾病复发时的作用。自2019年一来，主要致力于阐明白血病细胞逃逸NK 细胞免疫监视的新机制，探寻基于NK细胞的新型免疫治疗靶标与治疗策略，并开展临床试验。

相关研究成果主要包括：

(1). Dongyao Wang, Zimin Sun*, Xiaoyu Zhu*, Xiaohu Zheng, Yonggang Zhou, Yichen Lu, Peidong Yan, Huiru Wang, Huilan Liu, Jing Jin, Huaiping Zhu, Rui Sun, Yi Wang, Binqing Fu, Zhigang Tian and Haiming Wei*. GARP-mediated active TGF-β1 induces bone marrow NK cell dysfunction in AML patients with early relapse post-allo-HSCT. Blood. 2022 Dec 29;140(26):2788-2804. 

(2). Dongyao Wang^#, Binqing Fu^#, Xiaokun Shen, Chuang Guo, Yanyan Liu, Junfei Zhang, Rui Sun, Ying Ye, Jiabin Li*, Zhigang Tian*, Haiming Wei*. Restoration of HBV-specific CD8+ T cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy. Signal Transduction and Targeted Therapy. 2021 Nov 5;6(1):376. 

(3). Haoting Chen^#, Dongyao Wang^#, Yuying Yao^#, Yafang Xiao^#, Zhuangzhuang Zhao, Ziqi Zhang, Shaoyu Liu, Xinlu Wang, Shiying Yang, Panpan Huang, Zijian Zhou*, Xiaoyu Zhu*, Weisheng Guo*. Leukemia cell hitchhiking hypoxia responsive nanogel for improved immunotherapy of acute myeloid leukemia. Advanced Functional Materials. 2024 Aug (Accept).

(4).Zhao X#, Wang W#, Nie S, Geng L, Song K, Zhang X, Yao W, Qiang P, Sun G, Wang D*^#, Liu H*. Dynamic comparison of early immune reactions and immune cell reconstitution after umbilical cord blood transplantation and peripheral blood stem cell transplantation. Frontiers in immunology. 2023 Apr 11;14:1084901.

(5). Jin J^#, Bai L^#, Wang D^#, Ding W, Cao Z, Yan P, Li Y, Xi L, Wang Y, Zheng X, Wei H*, Ding C*, Wang Y*. SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth.EMBO reports. 2023 May 4;24(5):e56052.

(6). Pan T, Ding P, Huang A, Tang B, Song K, Sun G, Wu Y, Yang S, Chen X, Wang D^*, Zhu X^*. Reconstitution of double-negative T cells after cord blood transplantation and its predictive value for acute graft-versus-host disease. Chinese medical journal. 2023 Aug 24.

(7). Dongyao Wang^#, Dong Wang#, Min Huang#, Xiaohu Zheng, Yiqing Shen, Binqing Fu, Zhigang Tian, Wuxiang Guan*, Guiqiang Wang*, Haiming Wei*. Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA. Journal of Molecular Cell Biology. 2021 Dec 30;13(10):748-759.

(8). Dongyao Wang; Xiaohu Zheng; Binqing Fu; Zhigang Nian; Yeben Qian; Rui Sun; Zhigang Tian*; Haiming Wei*; Hepatectomy promotes recurrence of liver cancer by  enhancing IL-11-STAT3 signaling, EBioMedicine. 2019, 46(2019):119-132. 

(9). Yonggang Zhou^#, Jinhe Zhang^#, Dongyao Wang^#, Dong Wang, Wuxiang Guan, Jingkun Qin, Xiuxiu Xu, Jingwen Fang, Binqing Fu, Xiaohu Zheng, Dongsheng Wang, Hong Zhao, Xianxiang Chen, Zhigang Tian, Xiaoling Xu, Guiqiang Wang^*, Haiming Wei^*, Profiling of the immune repertoire in COVID-19 patients with mild, severe, convalescent, or retesting-positive status, Journal of Autoimmunity. 2021 Mar;118:102596. 

(10). Xingchi Chen^#, Dongyao Wang ^#, Xiaoyu Zhu^*. Application of double-negative T cells in haematological malignancies: recent progress and future directions. Biomarker research. 2022 Mar 14;10(1):11.