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特任研究员
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学位：博士
本课题组长期专注于代谢酶的研究，发展了化学生物学、细胞生物学和结构生物学交叉的原创性研究方法，围绕Sirtuins家族开展了深入系统的功能研究。已经鉴定出SIRT6、SIRT2和SIRT3分别为去长、中、短链脂肪酸修饰的去酰化酶，并发现由SIRT5调控的琥珀酰化修饰的阅读器。系列工作以通讯作者发表在J. Am. Chem. Soc.（2016）上，以第一/共第一作者发表在Nature（2013）、PNAS（2018）、Cell Chem Biol（2017）、eLife（2014）等国际期刊上。
- 11.Zhen Tong, Yi Wang, Xiaoyu Zhang, David D. Kim, Sushabhan Sadhukhan, Quan Hao, and Hening Lin. SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context. ACS Chem. Biol. 2016, 11, 742−747.2021,
- 10.Shrestha Ghosh, Baohua Liu, Yi Wang, Quan Hao, Zhongjun Zhou. Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair. Cell report. 2015, 1396–1406.2021,
- 9.Yusheng Xie, Jingyan Ge, Haipeng Lei, Bo Peng, Huatang Zhang, Danyang Wang, Sijun Pan, Ganchao Chen, Lanfang Chen, Yi Wang, Quan Hao, Shao Q. Yao, Hongyan Sun. Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases J. Am. Chem. Soc., 2016, 138 (48), pp 15596–15604.2021,
- 8.Zhen Tong, Miao Wang, Yi Wang, David D. Kim, Jennifer K. Grenier, Ji Cao, Sushabhan Sadhukhan, Quan Hao, and Hening Lin. SIRT7 is an RNA-activated protein lysine deacylase. ACS Chem. Biol. 2016, DOI: 10.1021/acschembio.6b00954. .2021,
- 7.Ghosh S, Wong SK, Jiang Z, Liu B, Wang Y, Hao Q, Gorbunova V, Liu X, Zhou Z. Haploinsufficiency of Trp53 dramatically extends the lifespan of SIRT6-deficient mice. Elife. 2018, Feb 23;7. pii: e32127..2021,
- 6.Xiucong Bao*, Yi Wang*, Xin Li*, Xiao-Meng Li*, Zheng Liu, Tangpo Yang, Chi Fat Wong, Jiangwen Zhang, Quan Hao, Xiang David Li. Identification of ‘erasers, SIRT3’ for lysine crotonylated histone marks using a chemical proteomics approach. Elife.2014; 3: e02999. (* co-first author) (Impact Factor, 7.551).2021,
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