点击次数：

影响因子：5.1

DOI码：10.1016/j.ceramint.2025.01.285

发表刊物：Ceramics International

摘要：Hydroxyapatite (HA) nanocrystals in bones typically exhibit a layered structure, characterized by extensive exposure of (100) facet and uniaxial orientation with organic collagen fibers. However, the inherent brittleness of traditional hydroxyapatite particles often complicates the achievement of optimal structural and property characteristics in subsequent composite preparations. Researchers found that high aspect ratio and small crystal size can greatly improve the rigidity of hydroxyapatite. In this study, we synthesized "bamboo lamellar"-like hydroxyapatite particles (LHA) that combine the biological advantages of exposed crystal planes with the mechanical benefits of a higher aspect ratio. We investigated the effects of the calcium complexing agent stearic acid and the alkaline regulator urea on the morphology of LHA samples using XRD, SEM, and TEM, with all final samples exhibiting pronounced laminar characteristics. Biocompatibility studies with pre-osteoblast MC3T3-E1 cells demonstrated that the LHA series samples displayed superior biocompatibility compared to commercially available hydroxyapatite. Alkaline phosphatase (ALP) activity assays indicated that LHA significantly outperformed commercial hydroxyapatite in promoting bone induction. Additionally, MC3T3-E1 cells adhered well to the surface of the LHA film. Incorporating LHA into a chitosan matrix significantly enhanced performance compared to both the pure organic matrix and the commercial hydroxyapatite control group. Thus, this " bamboo lamellar " biomimetic hydroxyapatite particle shows great potential as both an organic enhancer and a promoter of pre-osteoblast-induced bone formation, positioning it as a promising material for bone tissue engineering.

合写作者：Siyi Xue,Yufeng Huang,Yangyang Li

第一作者：Chao Wang

论文类型：期刊论文

通讯作者：Xiao Ma

是否译文：否

发表时间：2025-01-15

收录刊物：SCI

发布期刊链接：https://www.sciencedirect.com/science/article/abs/pii/S0272884225003128?via%3Dihub