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Fullerene-based polymer solar cells (PSCs) have been attracting great interest and showing bright prospect for inexpensive solar energy conversion. So far the most efficient architecture to build fullerene-based PSCs is the bulk heterojunction (BHJ) structure comprising of an interpenetrating network of a p-type conjugated polymer donor (e.g. P3HT) and a soluble n-type fullerene acceptor (e.g. PCBM) as the photoactive layer. The highest record for the power conversion efficiencies obtained in laboratory for fullerene-based PSCs is 11.5%. In addition to the effort to develop novel fullerene derivative acceptors, currently we also focus on improving the device efficiency via interface engineering (incoporating novel cathode/anode buffer layers) or doping in active layer.