Scientific Research

Research Field

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Paper Publications

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• Cheng A#,Xu T#,You W,Wang T,Zhang D,Guo H,Zhang H,Pan X,Wang Y,Liu L,Zhang K,Shi J,Yao X.Guo J*,Yang Z*.A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells..Nat. Metab.,2023,
• An analysis of clinical characteristics and prognosis of endometrioid ovarian cancer based on the SEER database and two centers in China..BMC Cancer,2023,
• Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression..J Biol. Chem.,2022,
• Energy restriction causes metaphase delay and chromosome mis-segregation in cancer cells..Cell Cycle,2021,
• Aurora-A inhibition eliminates myeloid cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in breast cancer.Cancer Research,2019,
• Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B Feedback Loop in late G2 phase.Cell Discovery,2017,

Patents

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Published Books

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Research Projects

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• 中国科大-长春卓谊联合实验室2020年课题5（通过靶向激酶Aurora-A多途径增敏NK细胞治疗的临床前研究）,进行,
• 肿瘤细胞分裂期NADPH的动态变化、调控机制及功能研究,进行,
• 药物治疗引起肿瘤细胞铁死亡的机制研究和应用探索,进行,
• 肿瘤细胞在药物作用后的命运决定机制,进行,
• 有丝分裂阻滞期选择性翻译受体Notch2调控细胞行为和命运的机制研究,进行,
• 稳态强磁场对肿瘤和非肿瘤细胞有丝分裂的影响及机制,进行,