实验室利用离体电生理、在体钙成像、光遗传、化学遗传、小动物磁共振成像等技术解析感觉（包括痛觉、痒觉）、情绪及其交互的神经机制。
主要研究兴趣为：
1.疼痛的神经机制（Neuron, 2018; iScience, 2023）
2.不同躯体感觉交互的神经机制
3.感觉-情绪交互的神经机制（Nature Communications, 2023）
4.不同病因抑郁症发病机制探索（Cell Reports, 2023）
- Wang XY#, Jia WB#, Xu X, Chen R, Wang LB, Su XJ, Xu PF, Liu XQ, Wen J, Song XY, Liu YY, Zhang Z*, Liu XF*, Zhang, Y*. A glutamatergic DRN-VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice. Nature communications, 2023, 14(1): 5124..
- Wang XY#, Xu X#, Chen R#, Jia WB, Xu PF, Liu XQ, Zhang Y*, Liu XF*, Zhang Y*. The thalamic reticular nucleus-lateral habenula circuit regulates depressive-like behaviors in chronic stress and chronic pain. Cell reports, 2023, 42(10): 113170. .
- Wang LB#, Su XJ#, Yan JJ, Wu QF, Xu X, Wang XY, Liu XQ, Song XY, Zhang Z, Hu W*, Liu XF*, Zhang Y*. Involvement of Mrgprd-expressing nociceptors-recruited spinal mechanisms in nerve injury-induced mechanical allodynia. iScience, 2023, 26(5): 106764..
- Wang LB#, Su XJ#, Wu QF, Xu X, Wang XY, Chen M, Ye JR, Maimaitiabula A, Liu XQ, Sun W*, Zhang Y*. Parallel Spinal Pathways for Transmitting Reflexive and Affective Dimensions of Nocifensive Behaviors Evoked by Selective Activation of the Mas-Related G Protein-Coupled Receptor D-Positive and Transient Receptor Potential Vanilloid 1-Positive Subsets of Nociceptors. Front. Cell. Neurosci., 2022, 16:910670. doi.org/10.3389/fncel.2022.910670.
- Chen R, Xu X, Wang XY, Jia WB, Zhao DS, Liu N, Pang Z, Liu XQ, Zhang, Y*. The lateral habenula nucleus regulates pruritic sensation and emotion. Molecular brain, 2023, 16, 54..
- Zhi YR, Cao F, Su XJ, Gao SW, Zheng HN, Jiang JY, Su L, Liu J, Wang Y, Zhang Y*, Zhang Y*. The T-Type Calcium Channel Cav3.2 in Somatostatin Interneurons in Spinal Dorsal Horn Participates in Mechanosensation and Mechanical Allodynia in Mice. Front. Cell. Neurosci., 2022, 16:875726. doi: 10.3389/fncel.2022.875726. .
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