1、 聚焦肿瘤/自身炎症免疫微环境，从代谢角度，解析NK等免疫效应细胞失能的新机制；
2、剖析肿瘤/自身炎症免疫微环境障碍因素，寻找新型免疫检查点；
3、利用合成免疫学理念，设计和组装免疫新分子，形成新型免疫干预方式。
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- Li S, Wang T, Xiao X, Zheng X, Sun H, Sun R, Ma H, Tian Z, Zheng X. Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies. Cancer Biol Med. 2024 Feb 29;21(4):331–46..Cancer Biol Med,2024,
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- Ye X, Yu Y, Zheng X, Ma H. Clinical immunotherapy in pancreatic cancer. Cancer Immunol Immunother. 2024 Mar 2;73(4):64.Cancer Immunol Immunother.,2024,
- Zhigang Nian, Xiaohu Zheng*, Yingchao Dou, Xianghui Du, Li Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Haiming Wei*, Rapamycin pretreatment rescues the bone marrow AML cell elimination capacity of CAR-T cells, Clinic Cancer Research, 2021, DOI: 10.1158/1078-0432. (IF=12.703).
- Xiaohu Zheng#*, Zhuanghao Hou#, Yeben Qian, Yongwei Zhang, Quanwei Cui, Xuben Wang, Yiqing Shen, Zhenbang Liu, Yonggang Zhou, Binqing Fu, Rui Sun, Zhigang Tian*, Guangming Huang* and Haiming Wei*. Tumors evade immune cytotoxicity by altering the surface topology of NK cells..Nature Immunology,2023,
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- 魏海明；粘志刚；郑小虎；孙汭；田志刚；用于白血病的CAR T 细胞疗法的T 细胞增效剂及获得增效T 细胞的方法；2020-10-29，中国， 202011176773.7,
- 魏海明；徐晓玲；周永刚；傅斌清；郑小虎；王东升；IL-6受体抗体的新用途；2020-02-19，中国， 202010103449.6,
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