1、 聚焦肿瘤/自身炎症免疫微环境，从代谢角度，解析NK等免疫效应细胞失能的新机制；
2、剖析肿瘤/自身炎症免疫微环境障碍因素，寻找新型免疫检查点；
3、利用合成免疫学理念，设计和组装免疫新分子，形成新型免疫干预方式。
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- [2] Xiaohu Zheng*, Yaqi Wu, Jiacheng Bi, Yingying Huang, Ying Cheng, Yangyang Li, Yuwei Wu, Guoshuai Cao, Zhigang Tian*, The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy. Cell Mol Immunol. 2022 Feb;19(2):192-209 (IF=11.531).
- [3] Defeng Jiao, Xiaohu Zheng*, Xianghui Du, Dong Wang, Ziming Hu, Rui Sun, Zhigang Tian, Binqing Fu*, and Haiming Wei*, Immunogenic senescence sensitizes lung cancer to LUNX-targeting therapy. Cancer Immunol Immunother. 2021 Oct 21. doi: 10.1007/s00262-021-03077-1 (IF=6.968).
- [4] Zhigang Nian, Xiaohu Zheng*, Yingchao Dou, Xianghui Du, Li Zhou, Binqing Fu, Rui Sun, Zhigang Tian, Haiming Wei*, Rapamycin pretreatment rescues the bone marrow AML cell elimination capacity of CAR-T cells, Clinic Cancer Research, 2021, DOI: 10.1158/1078-0432. (IF=12.703).
- [5] Jiacheng Bi, Chaoyue Zheng and Xiaohu Zheng*. Increased expression of adenosine A3 receptor in tumor-infiltrating natural killer cells. Cell Mol Immunol. 2021, DOI: 10.1038/s41423-020-00632-1. (IF=11.531).
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- 魏海明；粘志刚；郑小虎；孙汭；田志刚；用于急性髓系白血病的细胞疗法的嵌合抗原受体；2020-10-29，中国， 202011178806.1,
- 魏海明；粘志刚；郑小虎；孙汭；田志刚；用于白血病的CAR T 细胞疗法的T 细胞增效剂及获得增效T 细胞的方法；2020-10-29，中国， 202011176773.7,
- 魏海明；徐晓玲；周永刚；傅斌清；郑小虎；王东升；IL-6受体抗体的新用途；2020-02-19，中国， 202010103449.6,
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