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Scientific Research
梁陆军
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Special Associate Researcher
Scientific Research
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Liang, L.-J.#, Wang, Y.#, Hua, X.#, et al. Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time-Resolved Monitoring of Substrate Ubiquitination in Live Cells. JACS Au 2023, DOI: 10.1021/jacsau.3c00421.
Liang, L.-J. #, Chu, G.-C. #, Qu, Q. #, Zuo, C., Mao, J.-X, Zheng, Q.-Y, Chen, J.-N, Meng, X.-B, Jing, Y.-W, Deng, H.-T, Li, Y.-M., Liu, L. Chemical Synthesis of Activity-Based E2-Ubiquitin Probes for the Structural Analysis of E3 Ligase-Catalyzed Transthiolation. Angew. Chem. Int. Ed. 60, 2021, 17171-17177..
Pan, M.#, Zheng, Q. -Y. #, Wang, T. #, Liang, L. -J #, Mao, J.-X, Zuo, C., Ding, R.-C, Ai, H.-S, Xie, Y., Si, D., Yu, Y.-Y, Liu, L., Zhao, M-L. Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature. 600, 2021, 334-338..
Liang, L.-J., Si, Y.-Y, Tang, S., Huang, D.-L, Wang, Z.A., Tian, C.-L, Zheng, J.-S. Biochemical properties of K11,48-branched ubiquitin chains. Chin. Chem. Lett. 29, 2018, 1155-1159.
Zhang, Z.-Q., Yang, C.-T., Liang, L.-J., Xiao, B., Lu, X., Liu, J.-H., Sun, Y.-Y., Marder, T.B., Fu, Y. Copper-catalyzed/promoted cross-coupling of gem -diborylalkanes with nonactivated primary Alkyl halides: An alternative route to alkylboronic esters. Org. Lett. 16, 2014, 6342-6345.
Tan, X.-L., Pan, M., Zheng, Y., Gao, S., Liang, L.-J., Li, Y.-M. Sortase-mediated chemical protein synthesis reveals the bidentate binding of bisphosphorylated p62 with K63 diubiquitin. Chem. Sci. 8, 2017, 6881-6887.
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Research Projects
化学半合成基于活性的E2-Ub探针及用于E3酶功能机制解析,中国博士后基金会,
化学捕获”策略解析Cullin E3酶催化泛素链延伸的分子机制,已结题,中国博士后科学基金会,