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教授
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学位：博士
有机硼自由基化学
自由基反应是化学键转化的基本途径之一，由于其反应机制有别于传统离子型反应，因而给近代合成化学注入了新的思想和活力。迄今，关于碳、氮、氧等元素的自由基化学发展迅速。然而，处于同周期的硼元素因其缺电子的性质，被普遍认为很难应用于自由基反应。找到解决该难点的突破口，有望发现新的反应机制，从而给物质科学和生命科学的发展带来新的驱动力。我们课题组围绕该挑战性课题开展研究工作，致力于发展有机硼自由基全新的反应体系。我们将通过调控硼自由基的结构和性质，力争在碳-硼键的构建、选择性控制和惰性键活化等方面取得进展。
- 47. Chang-Ling Wang†, Jie Wang†, Ji-Kang Jin†, Bin Li, Yee Lin Phang, Feng-Lian Zhang*, Tian Ye, Hui-Min Xia, Li-Wen Hui, Ji-Hu Su, Yao Fu*, Yi-Feng Wang* Boryl radical catalysis enables asymmetric radical cycloisomerization reactions. Science, 2023, 382, 1056-1065..
- 46. You-Jie Yu,† Feng-Lian Zhang,† Tian-Yu Peng, Chang-Ling Wang, Jie Cheng, Chen Chen, Kendall N. Houk*, Yi-Feng Wang* Sequential C-F bond functionalizations of trifluoroacetamides and acetates via spin-center shifts, Science, 2021, 371, 1232-1240.
- 45. Tian-Yu Peng,† Feng-Lian Zhang,†, Yi-Feng Wang* Lewis Base-Boryl Radicals Enabled Borylation Reactions and Selective Activation of Carbon-Heteroatom Bonds, Acc. Chem. Res. 2023, 56,169-186..
- 44. Qiang Zhao,† Bin Li,† Xi Zhou, Zhao Wang, Feng-Lian Zhang,* Yuanming Li, Xiaoguo Zhou, Yao Fu,* and Yi-Feng Wang* Boryl Radicals Enabled a Three-Step Sequence to Assemble All-Carbon Quaternary Centers from Activated Trichloromethyl Groups, J. Am. Chem. Soc. 2022, 144, 15275-15285.
- 43. Tian-Yu Peng,† Zhe-Yuan Xu,† Feng-Lian Zhang*, Bin Li, Wen-Ping Xu, Yao Fu*, Yi-Feng Wang* Dehydroxylative Alkylation of α-Hydroxy Carboxylic Acids Derivatives via Spin-center Shift. Angew. Chem. Int. Ed. 2022, e202201329.
- 42. Feng-Lian Zhang, Bin Li, K. N. Houk*, Yi-Feng Wang* Application of the Spin-Center Shift in Organic Synthesis. JACS Au, 2022, 2, 1032-1042.
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