许超 博士生导师  

许  超，男，教授，博士生导师。2000年在中国科学技术大学生命科学学院获得本科学位，2000年、2005年在中国科学技术大学生命科学学院分别获得本科与博士学位。2006-2008年在美国Mayo Clinic作博士后，2009-2015年在多伦多大学结构基因组联盟从事真核基因转录调控和RNA修饰的结构生物学研究。2015年入选国家海外高层次人才引进计划青年项目。作为负责人承担自然科学基金重大研究计划集成项目（2022），重点项目（2021）。主要研究兴趣：运用结构生物学、化学生物学、细胞生物学等技术手段，研究真核生物中生物大分子化学修饰,包括蛋白质翻译后修饰与核酸修饰产生、消除和识别的分子机制，以及这些修饰异常的致病（肿瘤和神经退行性疾病等）机理。并通过化学小分子筛选辅助药物设计达到控制或者治疗疾病的目的，积极推进结构生物学向疾病治疗方向的转化。

已发表科研论文>80篇，总引用>4500次(Web of Science)。其中>40篇为第一作者（含共同第一作者）或通讯作者，发表在Cell，Nature Chemical Biology, Nature Structural & Molecular Biology, Cell Research, Nature Communications, PNAS 等国内外期刊上。

近期代表论文（*:通讯作者; #:共同第一作者）：

2016年加入中国科学技术大学以后 (含2016):

1. #Chen X, #Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, *Koren I, *Zhang K, *Xu C. Mechanism of Ψ-Pro/C-degron recognition by the CRL2^FEM1B ubiquitin ligase. Nat. Commun. 15: 3558. (2024).

2. #Zhao S, #Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, *Koren I, *Zhang K, *Xu C. Molecular basis for C-degron recognition by CRL2^APPBP2 ubiquitin ligase. Proc Natl Acad Sci U S A. 120: e2308870120. (2023).

3. #Chen Z, #Lundy T, Zhu Z, Hoskins V, Zhang J, Yao Z, *Strahl B, *Xu C. Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4. Cell.  Discov. 9: 51. (2023).

4. #Wang X, #Xie H, Guo Q, Cao D, Ru W, Zhao S, Zhu Z, Zhang J, Pan W, Yao X, *Xu, C. Molecular basis for METTL9-mediated N1-histidinemethylation. Cell.  Discov. 9: 38. (2023).

5. Guo Q, Chen X, *Xu, C. TRIM-away via Gln/C-degrons. Nat. Chem. Biol. 18, 1168–1169. (2022).

6. #Guo Q, #Zhao S, #Francisco-Velilla R, Zhang J, Embarc-Buh A, Abellan S, Lv M, Tang P, Gong Q, Shen H, Sun L, Yao X, Min J, Shi Y, *Martínez-Salas E, *Zhang K, *Xu C. Structural basis for Gemin5 decamer-mediated mRNA binding. Nat. Commun. 13: 5166. (2022).

7. #Wang X., #Zeng C., #Liao S., Zhu Z., Zhang J., Tu X., Yao X., *Feng X., *Guang S., *Xu C. Molecular basis for PICS-mediated piRNA biogenesis and cell division. Nat. Commun. 12: 5595. (2021).

8. #Chen X., #Liao S., #Makaros Y., Guo Q., Zhu Z., Krizelman R., Dahan K., Tu X., Yao X., *Koren I., *Xu C. Molecular basis for arginine C-terminal degron recognition by Cul2^FEM1 E3 ligase. Nat. Chem. Biol. 17, 254-262. (2021).

9. #Liao S., #Rajendraprasad G., #Wang N., Eibes S., Gao J., Yu H., Wu G., Tu X., *Huang H., *Barisic M., *Xu C. Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res. 29, 533-547. (2019).

10. #Guo Q., #Liao S.,#Kwiatkowski S., Tomaka W., Yu H., Wu G., Tu X., Min J., *Drozak J., *Xu C. Structural insights into SETD3-mediated histidine methylation on β-actin. eLife 8: e43676. (2019).

Before 2016:

1. *#Xu C., #Wang X., #Liu K., Roundtree I., Tempel W., Li Y., Lu Z., *He C., *Min J. Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain. Nat. Chem. Biol. 10, 927-929. (2014). (Recommended by Faculty of 1000). 

2. #Ni Z., #Xu C., Guo X., Hunter G., Kuznetsova O., Tempel W., Marcon E., Zhong G., Guo H., Kuo W., Li J., Young P., Olsen J., Wan C., Loppnau P., Bakkouri M., Senisterra, G., He H., Huang H., Sidhu S., Emili A., Murphy S., Mosley A., Arrowsmith C., *Min J., *Greenblatt J. RPRD1A and RPRD1B Serve as RNA Polymerase II Carboxyl-Terminal Domain Scaffolds to Recruit RPAP2 for Serine 5 Dephosphorylation. Nat. Struct. Mol. Biol. 21, 686-695. (2014).

3. #Xu Y., #Xu C., #Kato A., Tempel W., Abreu J.C., Bian C., Hu Y., Hu D., Zhao B., Cerovina T., Diao J., Wu F., He H.H., Cui Q., Clark E., Ma C., Barbara A., Veenstra G.J.C., Xu G., Kaiser U.B., Liu X.S., Sugrue S.P., He X., *Min J., *Kato Y., *Shi Y.G. Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for XenopusEye and Neural Development. Cell 151, 1200-1213. (2012).

4. #Xu C., #Jin J., Bian C., Lam R., Tian R., Weist R., You L., Nie J., Bochkarev A., Tempel W., Tan C., Wasney G., Vedadi M., Gish G., Arrowsmith C., Pawson T., Yang X., *Min J. Sequence-specific Recognition of a PxLPxI/L Motif by the Ankyrin-repeat Tumbler Lock. Sci. Signal. 5, ra39. (2012). (cover article).

5. #Bian, C., #Xu C., #Ruan J., #Lee K., #Burke T., Tempel W., Barsyte D., Li J., Wu M., Zhou B., Fleharty B.E., Paulson A., Allali-Hassani A., Zhou J., Mer G., Grant P., *Workman J.L., *Zang J., *Min J. Structural Basis of Sgf29 Tandem Tudor Domains Selectively Binding Methylated Histone H3K4 to Regulate Enzymatic Activity of the SAGA Complex. EMBO J. 30, 2849-2842. (2011).

6. #Xu C., #Bian C., Lam R., Dong A. *Min J. Structural Basis of Selective Binding of Nonmethylated CpG islands by the CXXC Domain of CFP1. Nat. Commun. 2: 227. (2011).

7. #Xu C., #Bian C., #Yang W., Galka M., Ouyang H., Chen C., Qiu W., Liu H., Jones A., MacKenzie F., Pan P., *Li S., *Wang H., *Min J. Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc. Natl. Acad. Sci. 107, 19266-19271. (2010).