My research focuses on disease relevant protein complexes and protein-DNA complexes in epigenetics and RNA epeignetics. Epigenetics is the study of acquired changes in chromatin structure that arise independently of a change in the underlying DNA nucleotide sequence. Modificatoins of DNA, histone and RNA regulate the eukaryotic gene expression at different layers. Abnormal regulation of gene expression lead to a number of diseases including cancer, autoimmune and neurodegenerative diseases. We utilize structural biology, molecular biology and chemical biology to explore the molecular mechanism underlining the complicated regulatory mechanisms and to identify small molecules to treat human diseases.
- Molecular basis for Eaf3-mediated assembly of Rpd3S and NuA4.Cell Discov.,2023,9(1):51.
- Molecular basis for C-degron recognition by CRL2APPBP2 ubiquitin ligase.Proc Natl Acad Sci U S A.,2023,120(43):e2308870120.
- Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase.Nat Commun.,2024,15(1):3558.
- Molecular basis for METTL9-mediated N1-histidine methylation.Cell Discovery,2023,9(1):38.
- Structural basis for Gemin5 decamer-mediated mRNA binding.Nat. Commun.,2022,13(1):5166.
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