DOI number:10.1364/BOE.8.002519

Journal:Biomedical Optics Express

Abstract:Fiber-optic endomicroscopes open new avenues for the application of non-linear optics to novel in vivo applications. To achieve focus scanning in vivo, shape memory alloy (SMA) wires have been used to move optical elements in miniature endomicroscopes. However, this method has various limitations, making it difficult to achieve accurate and reliable depth scanning. Here we present a feedback-controlled SMA depth scanner. With a Hall effect sensor, contraction of the SMA wire can be tracked in real time, rendering accurate and robust control of motion. The SMA depth scanner can achieve up to 490 µm travel and with open-loop operation, it can move more than 350 µm within one second. With the feedback loop engaged, submicron positioning accuracy was achieved along with superior positioning stability. The high-precision positioning capability of the SMA depth scanner was verified by depth-resolved nonlinear endomicroscopic imaging of mouse brain samples.

Co-author:Wenxuan Liang,Honghua Guan,Yung-Tian A. Gau,Dwight E. Bergles

First Author:Ang Li

Correspondence Author:Xingde Li

Document Type:J

Volume:8

Issue:5

Page Number:2519-2527

Translation or Not:no

Date of Publication:2017-04-17

Included Journals:SCI

Links to published journals:https://opg.optica.org/boe/fulltext.cfm?uri=boe-8-5-2519&id=363054