yangxinxing
- Supervisor of Doctorate Candidates
- Supervisor of Master's Candidates
- Name (English):Xinxing Yang
- Name (Pinyin):yangxinxing
- E-Mail:
- Administrative Position:Principal investigator
- Education Level:With Certificate of Graduation for Doctorate Study
- Business Address:西区医算楼807
- Contact Information:xinxingyang@ustc.edu.cn
- Degree:Dr
- Alma Mater:Peking Univeristy
- Teacher College:Life Sciences
- Discipline:Biology
Contact Information
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- Scientific Research
Our laboratory is dedicated to unraveling the intricate ways bacteria control their division and growth down to the molecular level, while preserving their distinct cellular shapes.
By harnessing an array of advanced techniques—including molecular and cellular biology, biochemistry, super-resolution, and single-molecule fluorescence microscopy—we strive
to uncover the intricate structures and dynamic behaviors of cytoskeletal proteins in both different bacteria. Our goal is to explore how these proteins influence the
intricate processes of cell wall synthesis and decomposition.
Core Research Focus Areas:
1. Cell Division Mechanism:
Investigating the molecular intricacies behind the remodling of bacterial cell walls and outer membranes during cell division.
2. Cytoskeletal regulation:
Delving into how prokaryotic cytoskeletal proteins shape the three-dimensional form of bacterial cells.
3. New Imaging Techniques :
Developing cutting-edge, high-throughput super-resolution imaging and single-molecule detection techniques tailored for prokaryotic cells.
- Di Yan,Jinchan Xue.Jie Xiao,Zhixin Lyu,Xinxing Yang.Protocol for single-molecule labeling and tracking of bacterial cell division proteins.[J].STAR protocols,2023,
- Yang, X*., McQuillen, R., Lyu, Z., Phillips-Mason, P., De La Cruz, A., McCausland, J. W., ... & Xiao, J*. (2021). A two-track model for the spatiotemporal coordination of bacterial septal cell wall synthesis revealed by single-molecule imaging of FtsW. Nature microbiology, 6(5), 584-593..2021,
- Bohrer, C. H., Yang, X., Thakur, S., Weng, X., Tenner, B., McQuillen, R., ... & Xiao, J*. (2021). A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM. Nature Methods, 18(6), 669-677..2021,
- McCausland, J. W., Yang, X., Squyres, G. R., Lyu, Z., Bruce, K. E., Lamanna, M. M., ... & Liu, J*. (2021). Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism. Nature communications, 12(1), 1-13..2021,
- Yang, X., Lyu, Z., Miguel, A., McQuillen, R., Huang, K. C*., & Xiao, J*. (2017). GTPase activity–coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis. Science, 355(6326), 744-747..2021,
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