主要研究成果（共同第一或共同通讯作者）：

1.        Demin Xu # Xiangyang Chen #, Yan Kuang, Minjie Hong, Ting Xu, Ke Wang, Xinya Huang, Chuanhai Fu, Ke Ruan, Chengming Zhu*, Xuezhu Feng* and Shouhong Guang*, rRNA intermediates coordinate the formation of nucleolar vacuoles in C. elegans. Cell Reports, 2023. (共同通讯作者)

2.        Xinhao Hou #, Mingjing Xu #, Chengming Zhu #, Jianing Gao, Meili Li, Xiangyang Chen, Cheng Sun, Björn Nashan, Jianye Zang, Ying Zhou, Shouhong Guang, Xuezhu Feng. Systematic characterization of chromodomain proteins reveals an H3K9me1/2 reader regulating aging in C. elegans. Nature Communications, 2023. (共同第一作者)

3.        Xinya Huang#, Peng Cheng#, Chenchun Weng, Zongxiu Xu, Chenming Zeng, Xiangyang Chen*, Chengming Zhu*, Shouhong Guang*, and Xuezhu Feng* A chromodomain protein mediates heterochromatin-directed piRNA expression. PNAS, 2021. (共同通讯作者)

4.        Shimiao Liao#, Xiangyang Chen#, Ting Xu#, Qile Jin, Zongxiu Xu, Demin Xu, Xufei Zhou, Chengming Zhu*, Shouhong Guang* and Xuezhu Feng* Antisense ribosomal siRNAs inhibit RNA polymerase I-directed transcription in C. elegans. Nucleic Acids Research, 2021.(共同通讯作者)

5.        Chengming Zhu#, Qi Yan#, Chenchun Weng, Xinhao Hou, Hui Mao, Dun Liu, Xuezhu Feng and Shouhong Guang, Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA. PNAS, 2018. (共同第一作者)

6.        Hui Mao#, Chengming Zhu#, Dandan Zong, Chenchun Weng, Xiangwei Yang, Hui Huang, Dun Liu, Xuezhu Feng and Shouhong Guang, The Nrde Pathway Mediates Small-RNA-Directed Histone H3 Lysine 27 Trimethylation in C. elegans. Current Biology, 2015. (共同第一作者)

 

 

其它参与的研究成果：

7.        Ting Xu, Shimiao Liao, Meng Huang, Chengming Zhu, Xiaona Huang, Qile Jin, Demin Xu, Chuanhai Fu, Xiangyang Chen, Xuezhu Feng, Shouhong Guang. A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans. PLoS Genet. 2023 Feb 10;19(2):e1010628.

8.        Meng Huang #, Minjie Hong #, Xinhao Hou, Chengming Zhu, Di Chen, Xiangyang Chen, Shouhong Guang, Xuezhu Feng. H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans. Elife, 2022 Sep 20;11:e74812.

9.        Xinhao Hou, Chengming Zhu, Mingjing Xu, Xiangyang Chen, Cheng Sun, Björn Nashan, Shouhong Guang, Xuezhu Feng. The SNAPc complex mediates starvation-induced trans-splicing in Caenorhabditis elegans. J Genet Genomics. 2022 Oct;49(10):952-964.

10.     Ling-Li Li, Qi-Zhong Wu, Jie-Jie Chen, Yin-Hua Cui, Cheng-Ming Zhu, Bing-Yan Li, Zhen Guo, Wen-Wei Li. Mechanical Insights into Thiol-Mediated Synergetic Biotransformation of Cadmium and Selenium in Nematodes. Environ Sci Technol. 2021 Jun 1;55(11):7531-7540.

11.     Qi Yan, Chengming Zhu, Shouhong Guang and Xuezhu Feng, The Functions of Non-coding RNAs in rRNA Regulation. Frontiers in genetics 10, 290 (2019).

12.     Xiangyang Chen#, Fei Xu#, Chengming Zhu, Jiaojiao Ji, Xufei Zhou, Xuezhu Feng and Shouhong Guang, Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans. Scientific reports 4, 7581 (2014).

 

主持或参加科研项目（课题）情况（按时间倒序排序）：

1. 国家自然科学基金面上项目，32270583，SUMOylation修饰通过抑制UAD-2相分离过程调控piRNA 转录，2023/01–2026/12，54万元，在研，主持。

2. 国家自然科学基金青年项目，31900434，核糖体RNA的表观修饰参与核糖体RNA稳态维持及个体发育调控，2020/01–2022/12，25万元，在研，主持。

3. 中国博士后科学基金第12批特别资助，2019T120543，risiRNA和rRNA表观修饰参与核糖体RNA稳态维持, 2019/09–2021/09, 18万元，结题，主持。

4. 中国博士后科学基金面上资助一等资助，2018M640591，risiRNA参与核糖体RNA稳态维持的机理研究，2018/12-2020/09,资助金额8万元，结题，主持。

5. 安徽省自然科学基金项目青年项目，1808085QC82，rRNA 加工修饰缺失促进 risiRNA 生成，2018/07-2020/06，资助金额10万元，结题，主持。

表观遗传学

非编码RNA生成与功能

piRNA的转录调控和功能研究

相分离调控转录的机制研究